Glucose sensor

• US 10,426,384 B2
• Filed: 06/02/2015
• Issued: 10/01/2019
• Est. Priority Date: 06/03/2014
• Status: Active Grant

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer-Gesellschaft ZUR Forderung Der Angewandten Forschung EV
• Inventors: Frese, Ines, Klotzbucher, Thomas
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Mustansir, Abid A
• Application Number:
  US15/312,247
• Publication Number:
  US 20170086716A1
• Time in Patent Office: 1,582 Days
• CPC Class Codes: A61B 2090/306 using optical fibres
• CPC Class Codes: A61B 2090/309 using white LEDs
• CPC Class Codes: A61B 2560/0233 Optical standards
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 2562/168 Fluid filled sensor housings
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6876 Blood vessel

Abstract

A method for determining the glucose value in blood or in interstitial liquids and to a glucose sensor including a catheter which has one or more openings in the region of the distal end of the catheter; a first optical waveguide which is arranged in the catheter and which includes a coupling surface at the distal end of the optical waveguide; a measuring probe which is arranged in the region of the distal end of the catheter, is coupled to the coupling surface of the first optical waveguide, and has a mirror arranged opposite the coupling surface of the first optical waveguide and a detection chamber between the coupling surface of the first optical waveguide and the mirror; a detection liquid for glucose in the detection chamber; and a membrane which encloses at least the detection chamber filled with the detection liquid and which has a separation capacity of maximally 20 kDA.

Claims

1. A glucose sensor, comprising:

a catheter, having one or more openings in a region of its distal end,

a first optical waveguide arranged in the catheter with a coupling surface at its distal end,

a measuring probe disposed in the region of the distal end of the catheter and coupled to the coupling surface of the first optical waveguide, having a mirror disposed opposite the coupling surface of the first optical waveguide and a detection chamber between the coupling surface of the first optical waveguide and the mirror,

a detection fluid for glucose in the detection chamber,

a membrane, which encloses at least the detection chamber filled with the detection fluid and having a separation capacity of at most 20 kDa, and

a light source coupled to the first optical waveguide, wherein the light source is an infrared light source providing light with a wavelength between 800 nm and 3000 nm.

2. A glucose sensor according to claim 1, further comprising a measuring and evaluating device, which comprises a detector coupled to the first optical waveguide and designed to measure an intensity of light returning from the detection chamber through the first optical waveguide.

3. The glucose sensor according to claim 2, wherein the measuring and evaluating device is coupled to a reference channel and designed to measure an intensity of the light in the reference channel and compare it to the intensity of the light returning from the detection chamber through the first optical waveguide.

4. The glucose sensor according to claim 3, further including a reference probe, which is arranged in the catheter in the vicinity of the measuring probe and a second optical waveguide arranged in the catheter with a coupling surface at its distal end, wherein the reference probe and the second optical waveguide form the reference channel and the reference probe is coupled to the coupling surface of the second optical waveguide and comprises a mirror arranged opposite the coupling surface of the second optical waveguide and a reference measuring chamber between the coupling surface of the second optical waveguide and the mirror with a reference medium having a constant glucose concentration, and wherein the measuring and evaluating device comprises a detector coupled to the second optical waveguide.

5. The glucose sensor according to claim 4, wherein a reference medium is water or an aqueous solution.

6. The glucose sensor according to claim 4, wherein the reference probe comprises a partition, wherein the partition encloses the reference measuring chamber filled with the reference medium between the coupling surface of the second optical waveguide and the mirror and holds back the reference medium therein.

7. The glucose sensor according to claim 4, further including a flow channel, in which the reference probe and the measuring probe are arranged and which can receive the flow of detection fluid or the reference medium, wherein the membrane forms a wall section of the flow channel in the area of the measuring probe and holds back the detection fluid in the flow channel.

8. The glucose sensor according to claim 7, further including a delivery device, which is connected to the flow channel and designed to generate a flow of the detection fluid or the reference fluid through the flow channel.

9. The glucose sensor according to claim 8, wherein first the reference probe and then the measuring probe are arranged in the flow channel one after the other in the flow direction.

10. The glucose sensor according to claim 4, wherein the first and the second optical waveguide is a multimode fiber.

11. The glucose sensor according to claim 4, wherein the light source is coupled to the reference channel.

12. The glucose sensor according to claim 11, further including a beam divider hooked up between the light source and the first optical waveguide, which is designed to couple a first portion of the light into the first optical waveguide and supply a second portion of the light to the reference channel.

13. The glucose sensor according to claim 1, wherein the membrane is located between the coupling surface of the first optical waveguide and the mirror.

14. The glucose sensor according to claim 1, wherein the first optical waveguide is a multimode fiber.

15. The glucose sensor according to claim 1, wherein the light source comprises an LED or several LEDs.

16. A method for determining a glucose value in blood or in interstitial fluid, comprising the steps of bringing a measuring probe coupled to a coupling surface of a first optical waveguide, which comprises a mirror arranged opposite the coupling surface of the first optical waveguide and a detection chamber between the coupling surface of the first optical waveguide and the mirror, containing a detection fluid for glucose and enclosed by a membrane having a separation capacity of at most 20 kDa, into contact with the blood or the interstitial fluid, wherein the glucose depending on a concentration gradient diffuses out from the blood or the interstitial fluid into the detection fluid or from the detection fluid into the blood or the interstitial fluid, coupling light at a wavelength between 800 nm and 3000 nm into the first optical waveguide and guiding the light through the latter to the detection chamber, reflecting the light at the mirror and guiding back the light at the mirror through the first optical waveguide, while absorbing light in dependence on the glucose concentration in the detection fluid in the detection chamber, and measuring an intensity of the light returning from the detection chamber.

17. The method according to claim 16, comprising dividing a light beam, then coupling a first portion of the light into the first optical waveguide and supplying a second portion of the light to a reference channel, in which the intensity of the second portion of the light is measured, which is then compared with the measured intensity of the light returning from the detection chamber.

18. The method according to claim 17, wherein the reference channel has a second optical waveguide with a coupling surface and a reference probe in the vicinity of the measuring probe, which is coupled to the coupling surface of the second optical waveguide and comprises a mirror arranged opposite the coupling surface of the second optical waveguide and a reference measuring chamber between the coupling surface of the second optical waveguide and the mirror with a reference medium of constant glucose concentration, the second portion of the light is coupled into the second optical waveguide and guided through the latter to the reference measuring chamber, reflected at the mirror and taken back through the second optical waveguide, while light in dependence on the glucose concentration in the reference medium is absorbed in the reference measuring chamber, and the intensity of the light returning from the reference measuring chamber is measured and compared with the measured intensity of the light returning from the detection chamber.