Device for detaching parietal thrombi from a blood vessel

• US 10,426,511 B2
• Filed: 10/21/2013
• Issued: 10/01/2019
• Est. Priority Date: 11/05/2012
• Status: Active Grant

• Current Assignee: Universitätsklinikum Freiburg
• Original Assignee: Universitätsklinikum Freiburg
• Inventors: Hehrlein, Christoph
• Primary Examiner(s): Lynch, Robert A
• Application Number:
  US14/440,847
• Publication Number:
  US 20150289902A1
• Time in Patent Office: 2,171 Days
• CPC Class Codes: A61B 17/22031 Gripping instruments, e.g. forceps, for removing or smashing calculi A61B17/221 takes precedence
• CPC Class Codes: A61B 17/22032 having inflatable gripping elements balloon catheters A61M25/10
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22041 outside the catheter
• CPC Class Codes: A61B 2017/22045 fixed to the catheter; guiding tip
• CPC Class Codes: A61B 2017/22069 Immobilising; Stabilising
• CPC Class Codes: A61B 2017/22079 with suction of debris

Abstract

A device for detaching parietal thrombi from a bodily vessel is described having a catheter including at least one catheter section with a catheter wall with at least one wall opening which passes completely through the catheter wall. The catheter wall along the least one catheter section is made of a resiliently deformable material in which the at least one wall opening includes a separating helical gap wound around the catheter wall at least in parts along the catheter section. A fixing device permits releasable fixing of the catheter on a bodily vessel so that the catheter can be converted, exclusively by an external mechanical constraint in the form of a torque acting torsionally on the catheter, from a state of smaller catheter outer diameter to a state of larger catheter outer diameter.

Claims

1. A device for detaching a parietal thrombus from a body vessel comprising:

a catheter including at least one catheter section disposed longitudinally relative to the catheter;

a catheter wall including at least one wall opening passing completely through the catheter wall;

the catheter wall being disposed longitudinally relative to the least one catheter section and comprising a resiliently deformable material, the at least one wall opening including a separating gap wound helically with a constant pitch around the catheter wall at least in parts of the at least one catheter section including a cut passing completely through the catheter wall having two faces which include cutting edges that contact each other when the separating gap is closed, the catheter in a distal direction from the separating gap including a fixing device configured for releasably fixing the catheter to the body vessel;

means configured for severing at least part of the parietal thrombus from the body vessel including the cutting edges which are responsive to removal of torque acting on the catheter when the parietal thrombus is at least partially within the opening to sever the at least part of the parietal thrombus;

the catheter being configured so that torque acting on the catheter causes diameter of the catheter to expand from a smaller catheter outer diameter when the faces including the cutting edges contact each other to a larger catheter outer diameter which is constant along the catheter and causes the separating gap to change from being closed to being opened with the faces including the cutting edges being separated; and

the catheter, in an absence of an external constraint being applied thereto while the parietal thrombus is at least partially within the opening, is configured to spontaneously adopt the smaller catheter outer diameter due to resilient restoring forces of the resiliently deformable material causing the separating gap to close to activate the means configured for severing to cause the cutting edges to sever at least part of the parietal thrombus from the body when the parietal thrombus is at least partially within the opening; and

wherein

the fixing device comprises a dilatable balloon mounted on the catheter and is either spaced distally from the separating gap or is positioned distally from the catheter, and the balloon is inflatable by a lumen which is disposed along the lumen.

2. The device according to claim 1, wherein the catheter comprises an inner catheter lumen, the at least one catheter section is tubular, and the resiliently deformable material is an elastomer.

3. The device according to claim 2, wherein the elastomer is made of at least one material selected from:

poly(methyl methacrylate) (PMMA), polytetrafluoroethylene (PTFE), polyurethanes, polyether urethanes, silicone polyether urethanes, silicone polyurethanes, silicone polycarbonate urethanes, polyolefin elastomers, polyisobutylenes, fluorosilicones, polyvinyl chloride (PVC), polydimethylsiloxane (PDMS), polylactides, polyethylene, polybutylmethacrylate, polyacrylamide, polyacrylonitriles, polyamides, polyetheramides, polyethylene amine, polyimides, polycarbonates, polycarbonate urethanes, polyvinyl ketones, polyvinyl halides, polyvinylidene halides, polyvinyl ether, polyisobutylenes, polyvinyl aromates, polyvinyl ester, polyvinyl pyrrolidones, polyoxymethylenes, polytetramethylene oxide, nylon or polyester.

4. The device according to claim 1 wherein:

the at least one catheter section ranges from 1 cm to 100 cm in length, has a resilient section having a catheter outer diameter ranging from 1 mm to 25 mm and the catheter wall ranges in thickness, without influence of the external constraint to between 0.1 mm and 2.5 mm.

5. The device according to claim 1, wherein:

the separating gap along the at least one catheter section has at least one helical turn.

6. The device according to claim 1 wherein:

the catheter extends longitudinally, includes at least one first catheter section and includes a second catheter section which is axially separated from the at least one first catheter section, and the separating gap is formed in at least two catheter sections each wound in an identical winding direction.

7. The device according to claim 1, wherein:

the balloon is positioned inside a radially flexible stent which when the balloon is inflated the balloon is configured to contact a stent which is configured to radially expanded and contact an inner wall of the vessel.

8. The device according to claim 1 wherein:

the catheter at a proximal end includes a connector to which a vacuum source is attachable.

9. The device according to claim 1 comprising:

at least one radiopaque marking is mounted in a region of a catheter tip associated with at least one of the catheter and along the at least one catheter section.

10. The device according to claim 1 wherein:

the sectional faces of the cut are separated by the external constraint when the catheter is converted from the smaller outer diameter to the larger outer diameter and encloses the separation gap which has a pitch that is larger than a pitch associated with the separation gap when the catheter has the smaller outer diameter.

11. The device according to claim 10, wherein:

in the separation gap has a gap of a width b ranging from 0.1 mm≤

b≤

50 mm or 0.5 mm≤

b≤

10 mm.

12. The device according to claim 11, wherein in the at least one further wall opening includes a material cutout from a wall of the catheter and has a largest opening width ranging from 0.1 mm to 20 mm.

13. The device according to claim 1 comprising:

at least one further wall opening passing completely through the catheter wall along the at least one catheter section and the separating gap.

14. The device according to claim 1 wherein:

when the torque is removed, the means configured for severing comprises the faces which close and are configured to contact the parietal thrombus and sever the parietal thrombus from the vessel.