Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
First Claim
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1. A process for applying a laser radiation to at least one portion of a biological structure, comprising:
- a) providing a beam of the laser radiation to the at least one portion, wherein a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion;
b) applying the beam to the at least one portion (i) while modulating a wavelength of the laser radiation and (ii) while monitoring a depth of the application of the laser radiation;
c) receiving at least one return radiation from the at least one portion;
d) determining speckle information related to the at least one return radiation;
e) determining a laser damage depth within the biological structure based on the speckle information; and
f) adjusting a penetration depth of the beam by changing the wavelength of the laser radiation.
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Abstract
According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.
580 Citations
21 Claims
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1. A process for applying a laser radiation to at least one portion of a biological structure, comprising:
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a) providing a beam of the laser radiation to the at least one portion, wherein a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion; b) applying the beam to the at least one portion (i) while modulating a wavelength of the laser radiation and (ii) while monitoring a depth of the application of the laser radiation; c) receiving at least one return radiation from the at least one portion; d) determining speckle information related to the at least one return radiation; e) determining a laser damage depth within the biological structure based on the speckle information; and f) adjusting a penetration depth of the beam by changing the wavelength of the laser radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A process for applying a laser radiation to at least one portion of a biological structure, comprising:
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a) providing a beam of the laser radiation to the at least one portion, wherein a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion; b) applying the beam to the at least one portion (i) while modulating a wavelength of the laser radiation and (ii) while monitoring a depth of the application of the laser radiation; c) with the beam, causing a temperature change in a section of the biological structure which is near or in the at least one portion of the biological structure; d) determining a phase-shift of at least one return radiation provided from the section; e) identifying a deformation of the section at a plurality of depths as a function of the phase-shift of the at least one return radiation provided from the section; f) determining a laser damage depth within the biological structure based on the deformation of the section at the plurality of depths; and g) adjusting a penetration depth of the beam by changing the wavelength of the laser radiation.
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12. A system for applying a laser radiation to at least one portion of a biological structure, comprising:
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an optical configuration comprising an optical fiber configured to provide a beam of the laser radiation to the at least one portion, wherein a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion; a beam configuration configured to apply the beam to the at least one portion (i) while modulating a wavelength of the laser radiation, and (ii) while monitoring a depth of the application of the laser radiation; the optical configuration further configured to receive at least one return radiation from the at least one portion; and a processor configured to; determine a phase-shift of the at least one return radiation, identify a deformation within the at least one portion at a plurality of depths as a function of the phase-shift of the at least one return radiation, determine a laser damage depth within the biological structure based on the deformation within the at least one portion at the plurality of depths, and adjust a penetration depth of the beam by changing the wavelength of the laser radiation. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for applying a laser radiation to at least one portion of a biological structure, comprising:
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an optical configuration comprising an optical fiber configured to provide a beam of the laser radiation to the at least one portion, wherein a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion; a beam configuration configured to apply the beam to the at least one portion (i) while modulating a wavelength of the laser radiation, and (ii) while monitoring a depth of the application of the laser radiation, applying the beam causing a temperature change in a section of the sample which is near or in the at least one portion of the biological structure; and a processor configured to; determine a phase-shift of at least one return radiation provided from the section, identify a deformation of the section at a plurality of depths as a function of the phase-shift of the at least one return radiation provided from the section, determine a laser damage depth within the biological structure based on the deformation of the section at the plurality of depths, and adjust a penetration depth of the beam by changing the wavelength of the laser radiation.
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Specification