Membrane for covering a peripheral surface of a stent

• US 10,426,642 B2
• Filed: 10/09/2012
• Issued: 10/01/2019
• Est. Priority Date: 10/10/2011
• Status: Active Grant

• Current Assignee: Agency For Science Technology and Research, National University of Singapore
• Original Assignee: National University of Singapore
• Inventors: Ho, Pei, Leo, Hwa Liang, Ng, Sum Huan, Cui, Fangsen, Kabinejadian, Foad
• Primary Examiner(s): Schall, Matthew W
• Application Number:
  US14/350,690
• Publication Number:
  US 20140358221A1
• Time in Patent Office: 2,548 Days
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/2476 Valves implantable in the body not otherwise provided for
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0024 made from both porous and non-porous parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0071 breakable or frangible

Abstract

A membrane for covering a peripheral surface of a stent is provided, the membrane including a plurality of line openings formed therein. Each line opening may be a straight line opening, for example in the form of a slit, a curved line opening, or any line opening of a suitable shape or curvature, e.g. U-shaped or V-shaped. Blood pressure opens the slits to allow blood to flow through the membrane, while curved line openings create a flap in the membrane that can open to allow blood to pass through. According to further embodiments of the present invention, a method of forming a membrane on a stent and a device for use in a blood vessel are provided.

Claims

1. A membrane for covering a peripheral surface of an expandable stent configured to be received in a blood vessel, the membrane comprising a single layer having a plurality of line openings formed therein, each line opening comprising a slit or a flap and being configured for:

allowing, in an open state when covering the expanded stent in the blood vessel, blood from outside a lumen of the stent to flow inside the lumen and then out of respective gaps of the plurality of line openings into a branch area of the blood vessel,

at least substantially closing the gaps in a closed state when the membrane covers the stent and the stent is expanded to the wall of the blood vessel, and

changing from the closed state to the open state by expanding outwardly away from the expanded stent in response to blood flow in the lumen when the stent is expanded and resides at the branch area within the blood vessel.

2. The membrane as claimed in claim 1, wherein each line opening of the plurality of line openings is shaped to define a partial boundary of a portion of the membrane therewithin, wherein the portion defines a flap.

3. The membrane as claimed in claim 2, wherein each flap is pivotable relative to the membrane between (a) the open position in which the flap extends outwardly from the membrane thereby defining an opening in the membrane, and (b) the closed position in which the flap extends in line with the single layer of the membrane thereby at least substantially closing said opening.

4. The membrane as claimed in claim 1, wherein each line opening of the plurality of line openings is a straight line opening defining a slit, and wherein when the stent is in an expanded state within the blood vessel and each slit is in a closed position, pressures acting on portions of the membrane on opposing sides of each slit urge the portions of the membrane towards each other so as to provide a substantially tight closure of the slit.

5. The membrane as claimed in claim 1, wherein the membrane is a sleeve for receiving the stent.

6. The membrane as claimed in claim 5, wherein the sleeve has a tubular shape.

7. The membrane as claimed in claim 1, wherein the membrane is coatable on the peripheral surface of the stent.

8. A device for use in a blood vessel, the device comprising:

a stent configured to be received in the blood vessel, the stent comprising a luminal passage for flow of blood in the blood vessel when the stent is received in the blood vessel; and

a membrane configured to cover a peripheral surface of the stent, wherein the membrane comprises a single layer having a plurality of line openings formed therein, each line opening comprising a slit or flap and being configured for;

allowing, in an open state when covering the expanded stent in the blood vessel, blood from outside a lumen of the stent to flow inside the lumen and then out of respective gaps of the plurality of line openings into a branch area of the blood vessel,

at least substantially closing the gaps in a closed state when the membrane covers the stent and the stent is expanded to the wall of the blood vessel, and

changing from the closed state to the open state by expanding outwardly away from the expanded stent in response to blood flow in the lumen when the stent is expanded and resides at the branch area within the blood vessel.

9. The device as claimed in claim 8, wherein each line opening of the plurality of line openings is shaped to define a partial boundary of a portion of the membrane therewithin, wherein the portion defines a flap.

10. The device as claimed in claim 9, wherein each flap is formed in the membrane such that a connecting section of the membrane extending between two ends of the line opening is oriented at least substantially transverse to a longitudinal axis of the stent.

11. The device as claimed in claim 10, wherein each flap is pivotable relative to the membrane between (a) the open position in which the flap extends outwardly from the stent thereby defining an opening in the membrane, and (b) the closed position in which the flap extends in line with the single layer of the membrane thereby at least substantially closing said opening.

12. The device as claimed in claims 10, wherein the connecting section is configured to face an inflow end of the stent when placed in the blood vessel.

13. The device as claimed in claim 8, wherein each line opening of the plurality of line openings is a straight line opening defining a slit, and wherein when the stent is in an expanded state within the blood vessel and each slit is in a closed position, pressures acting on the portions of the membrane on opposing sides of each slit urge the portions of the membrane towards each other so as to provide a substantially tight closure of the slit.

14. The device as claimed in claim 8, wherein the membrane is a sleeve configured to receive the stent.

15. The device as claimed in claim 8, wherein the membrane is coated on the peripheral surface of the stent.