Drive mechanism and drug delivery device herewith

• US 10,426,895 B2
• Filed: 10/09/2015
• Issued: 10/01/2019
• Est. Priority Date: 10/09/2014
• Status: Active Grant

• Current Assignee: Sanofi
• Original Assignee: Sanofi
• Inventors: Marsh, William, Morris, Anthony Paul, Butler, Joseph, Jones, Matthew, Steel, Samuel, Avery, Richard James Vincent
• Primary Examiner(s): Stiles, Amber R
• Assistant Examiner(s): Chidiac, Nicholas J
• Application Number:
  US15/517,719
• Publication Number:
  US 20170312447A1
• Time in Patent Office: 1,453 Days
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/02 characterised by a particular materials
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31576 Constructional features or modes of drive mechanisms for piston rods
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod

Abstract

The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a pen type drug delivery device and to such a drug delivery device. The mechanism comprises a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member in a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member in a decoupled state, and a spring biasing the clutch into its coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring. The clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction.

Claims

1. A drive mechanism for a drug delivery device, the mechanism comprising a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member into a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member when in a decoupled state, and a spring biasing the clutch into the coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring, wherein the clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction, wherein the drive member is formed of polybutylene terephthalate (PBT), polyoxymethylene (POM), or polycarbonate (PC) and the rotatable driven member is formed of PBT, POM or PC, and a coefficient of friction (μ

) between the teeth on the drive member and the teeth on the driven member is between 0.05 and 0.3, and the teeth on the drive member and the teeth on the driven member have a surface roughness (Ra) of 0.2≤

Ra≤

10 micrometers.

2. The drive mechanism according to claim 1, wherein the drive member is formed of PBT and the rotatable driven member is formed of PBT, POM or PC.

3. The drive mechanism according to claim 1, wherein the drive member is formed of POM and the rotatable driven member is formed of POM or PC or wherein the material of the drive member is PC and the material of the rotatable driven member is PBT, or POM.

4. The drive mechanism according to claim 1, wherein the drive member is formed of PC and the rotatable driven member is formed of PBT or POM.

5. The drive mechanism according to claim 1, wherein the coefficient of friction (μ

) between the teeth is between 0.09 and 0.11.

6. The drive mechanism according to claim 1, wherein the teeth have a surface roughness (Ra) between 0.7 and 0.9.

7. The drive mechanism according claim 1, wherein the drive member is a separate component part which is rotationally constrained to a dose setting member.

8. The drive mechanism according to claim 1, further comprising a torsion spring which is directly or indirectly coupled to the drive member such that rotation of the drive member in a first rotational direction charges the spring and rotation of the drive member in a second, opposite rotational direction discharges the spring.

9. The drive mechanism according to claim 8, wherein the teeth have a steeper ramped tooth angle in the second rotational direction and have a shallower ramped tooth angle in the first rotational direction.

10. The drive mechanism according to claim 8, wherein the teeth have a higher friction coefficient in the second rotational direction and have a lower friction coefficient in the first rotational direction.

11. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising:

a drive mechanism comprising a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member into a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member when in a decoupled state, and a spring biasing the clutch into the coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring, wherein the clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction, wherein the drive member is formed of polybutylene terephthalate (PBT), polyoxymethylene (POM), or polycarbonate (PC) and the rotatable driven member is formed of PBT, POM or PC, and a coefficient of friction (μ

) between the teeth on the drive member and the teeth on the driven member is between 0.05 and 0.3, and the teeth on the drive member and the teeth on the driven member have a surface roughness (Ra) of 0.2≤

Ra≤

10 micrometers,

a housing,

a dose setting member located within the housing, and

a piston rod engaging the driven member,

wherein the drive member is operatively interposed between the driven member and the dose setting member.

12. The drug delivery device according to claim 11, further comprising a cartridge containing a medicament.

13. The drug delivery device according to claim 11, further comprising a second clutch for rotationally coupling and decoupling the driven member and the housing.

14. The drug delivery device according to claim 13, wherein the driven member is axially displaceable relative to the housing between a first position in which the second clutch rotationally couples the driven member and the housing and a second position in which the second clutch rotationally decouples the driven member from the housing.

15. The drug delivery device according to claim 13, wherein the teeth of the clutch are in the coupled state when the driven member and the housing are decoupled by the second clutch.

16. The drug delivery device according to claim 13, wherein the driven member and the housing are coupled by the second clutch when the teeth of the clutch are in the decoupled state.