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Mesoderm and definitive endoderm cell populations

  • US 10,428,308 B2
  • Filed: 08/28/2017
  • Issued: 10/01/2019
  • Est. Priority Date: 06/24/2005
  • Status: Active Grant
First Claim
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1. A method of making a cell population enriched for endoderm cells comprising culturing pluripotent stem cells in the presence of activin or nodal, and Wnt, for a time sufficient to provide brach+/HNF3β

  • + cells, and culturing said brach+/HNF3β

    + cells in the presence of activin and an inhibitor of Wnt signalling for a time sufficient to provide a cell population enriched for endoderm cells.

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