Apparatus and method for improved drug regimen compliance

• US 10,431,070 B2
• Filed: 03/01/2019
• Issued: 10/01/2019
• Est. Priority Date: 04/08/2016
• Status: Active Grant

• Current Assignee: Quantaed, Llc
• Original Assignee: Quantaed, Llc
• Inventors: Mehregany, Mehran
• Primary Examiner(s): Ghulamali, Qutbuddin
• Application Number:
  US16/290,656
• Publication Number:
  US 20190197872A1
• Time in Patent Office: 214 Days
• Field of Search: 3405681
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61J 2200/30 Compliance analysis for taking medication
• CPC Class Codes: A61J 2205/70 Audible labels, e.g. for pre-recorded info or messages
• CPC Class Codes: A61J 7/0436 resulting from removing a drug from, or opening, a container
• CPC Class Codes: A61J 7/0481 working on a schedule basis
• CPC Class Codes: G08B 21/24 Reminder alarms, e.g. anti-loss alarms
• CPC Class Codes: G16H 20/13 delivered from dispensers

Abstract

A method and apparatus for monitoring drug-regimen compliance is disclosed. Systems in accordance with the present invention enable automatic monitoring of the state of medicine content of a blister card. Each tablet location on the blister card is operatively coupled with a different sensor that detects whether the tablet location is occupied and/or a dispensing event at a tablet location. In some embodiments, capacitive sensing is employed, where the capacitance of each sensor is based on the physical state of a dispensing region of the lidding film of the blister pack, which is located at the tablet location being monitored. Alternative sensing approaches are based on optical, acoustic, and tactile sensors that interrogate either the dispensing region at each tablet location or the tablets themselves to determine whether tablets have been dispensed. The sensors interface with a mobile app that provides the user instructions to help improve drug-regimen compliance.

Claims

1. A system for monitoring the state of at least one blister card that includes a forming film, a lidding film, and a first tablet contained in a first reservoir defined by the forming film and the lidding film, wherein the system comprises:

a housing that is operative for locating the blister card in a first position, the housing including a lid having an open position and a closed position;

a first detection module comprising a first sensor that is operative for providing a first electrical signal based on at least one of (1) the presence of the first tablet in the first reservoir and (2) a first force applied to the forming film of the first reservoir; and

an electronics module that is operative for providing a first output signal based on the first electrical signal.

2. The system of claim 1 wherein the first sensor is a capacitive sensor that includes a first capacitor that is located on the lid, and wherein the first capacitor has a first capacitance when the lid is in its closed position and the first tablet is in the first reservoir, and further wherein the first capacitor has a second capacitance with the lid is in its closed position and the first tablet is not in the first reservoir.

3. The system of claim 2 wherein the first capacitor includes first and second electrodes that are disposed on the lid, and wherein the first capacitance is based on capacitive coupling between the first tablet and the first and second electrodes via a first fringing field.

4. The system of claim 3 wherein the second capacitance is based on capacitive coupling between the first reservoir and the first and second electrodes via a second fringing field.

5. The system of claim 1 wherein the electronics module is operative for providing the first output signal as a wireless signal.

6. The system of claim 1 wherein the first sensor includes a first tactile sensor that is configured to detect the first force.

7. The system of claim 6 wherein the first tactile sensor includes a first capacitor having first and second electrodes separated by a first separation, and wherein the first tactile sensor is disposed on the lid such that, when the lid is in its closed position, the first separation has a first magnitude when the first tablet is in the first reservoir and a second magnitude when the first tablet is not in the first reservoir.

8. The system of claim 6 further comprising a second tactile sensor that is operative for detecting a second force applied to the blister card in a first region that does not include the first reservoir.

9. A system that is operative for monitoring the state of a first blister card that includes a forming film, a lidding film, and a plurality of tablets that is arranged in a first arrangement, wherein each tablet of the plurality thereof is contained in a different reservoir of a plurality of reservoirs defined by the forming film and lidding film, wherein the system comprises:

a housing for locating the blister card, the housing comprising a lid having a closed position and an open position;

a first detection module comprising a first plurality of sensors arranged in the first arrangement such that there is a one-to-one correspondence between the first plurality of sensors and the first plurality of reservoirs, wherein a first sensor of the first plurality thereof is operative for providing a first electrical signal of a first plurality thereof such that the first electrical signal is based on at least one of (1) the presence of a first tablet of the plurality thereof in a first reservoir of the plurality thereof when the lid is in its closed position and (2) a first force applied to the forming film of the first reservoir; and

an electronics module operative for providing a first output signal based on the first plurality of electrical signals.

10. The system of claim 9 wherein the first sensor includes a tactile sensor that includes a capacitor having first and second electrodes separated by a first separation, and wherein the tactile sensor is disposed on the lid such that, when the lid is in its closed position, the first separation has a first magnitude when the first tablet is in the first reservoir and a second magnitude when the first tablet is not in the first reservoir.

11. The system of claim 9 wherein a first sensor of the first plurality thereof includes a capacitive sensor comprising a first capacitor disposed on the lid, and wherein the first capacitor has a first capacitance when the lid is in its closed position and the first tablet is in the first reservoir, and further wherein the first capacitor has a second capacitance with the lid is in its closed position and the first tablet is not in the first reservoir.

12. The system of claim 9 further comprising a tactile sensor that is operative for detecting a force applied to the blister card in a first region that does not include a reservoir of the plurality thereof.

13. A method for monitoring the state of a blister card that includes a forming film, a lidding film, and a plurality of tablets that is arranged in a first arrangement, wherein each tablet of the plurality thereof is contained in a different reservoir of a plurality of reservoirs defined by the forming film and lidding film, wherein the method comprises:

providing a housing for locating the blister card and a detection module, the housing including a lid having an open position and a closed position;

providing the detection module such that it comprises a plurality of sensors configured to provide a plurality of first electrical signals, each of the plurality of the first electrical signals based on a content of the different reservoir of the plurality thereof, wherein the plurality of sensors is arranged in the first arrangement such that there is a one-to-one correspondence between the plurality of sensors and the plurality of reservoirs, and wherein each sensor of the plurality of sensors consisting of (1) a capacitive sensor disposed on the lid, the capacitive sensor configured to provide its respective first electrical signal based on a capacitance that is based on the presence of a tablet in its respective reservoir when the lid is in its closed position or (2) a tactile sensor that is configured to provide its first electrical signal based on a force applied to the forming film of its respective reservoir;

determining a physical state of the blister card based on the plurality of first electrical signals;

comparing the physical state of the blister card with an expected state of the blister card, wherein the expected state is based on a predetermined prescription regimen for the plurality of tablets; and

providing an output signal based on the physical state of the blister card relative to the expected state.

14. The method of claim 13 wherein the physical state of the blister card is determined when the lid is moved from its open position to its closed position.

15. The method of claim 13 further comprising monitoring the time and date, wherein the expected state is based on the monitored time and date.

16. The method of claim 13 further comprising providing a second electrical signal when a force on the blister card is detected, the second electrical signal being provided by a tactile sensor that is operatively coupled with the blister card in a first region that does not include a reservoir of the plurality thereof.

17. The method of claim 13 further comprising initiating an error signal if the physical state and expected state are different.

18. The method of claim 13 wherein the detection module is provided such that a first sensor of the plurality thereof is a capacitive sensor comprising a first capacitor disposed on the lid, and wherein, when the lid is in its closed position, the first capacitor has a first capacitance when a first tablet is in the first reservoir and a second capacitance when first tablet is not in the first reservoir.

19. The method of claim 18 wherein the first capacitor includes first and second electrodes that are dispose on the lid, and wherein the first capacitance is based on a fringing field between the first tablet and the first and second electrodes.

20. The method of claim 13 wherein the detection module is provided such that a first sensor of the plurality thereof is a tactile sensor that includes a first capacitor having first and second electrodes separated by a first separation, and wherein the first sensor is disposed on the lid such that, when the lid is in its closed position, the first separation has a first magnitude when the first tablet is in the first reservoir and a second magnitude when the first tablet is not in the first reservoir.