Diagnostic method and apparatus for brain injury based on EMG frequency power spectra analysis

• US 10,433,757 B2
• Filed: 12/29/2015
• Issued: 10/08/2019
• Est. Priority Date: 02/02/2015
• Status: Active Grant

• Current Assignee: Jian Chen
• Original Assignee: Jian Chen
• Inventors: Chen, Jian
• Primary Examiner(s): Jang, Christian
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US15/526,025
• Publication Number:
  US 20180049662A1
• Time in Patent Office: 1,379 Days
• Field of Search: 600543
• CPC Class Codes: A61B 5/112 Gait analysis
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence

Abstract

A method and a device for diagnosing brain injury (e.g. concussion) based on analysis of electromyogram (EMG) signals and presence of neurological modulation impairment of motor activity are described. The method consists of recording specific EMG signals under defined conditions, processing the acquired EMG signals, extracting the relevant information, and making diagnosis of brain injury and disorders that are associated with brain pathology. Specifically, the steps and device involved in the method include placing an EMG electrode set on the subject'"'"'s body area, acquiring EMG signals from a subject'"'"'s muscle(s) undergoing contraction, processing the acquired EMG signals using a signal processing algorithm that includes Fourier transformation. The resulting EMG data with a frequency domain (frequency power spectra) are then analyzed in comparison with databases stored in the device and used to determine anomaly of diagnostic value in the EMG power spectra from subjects. A diagnosis can be made based the altered EMG frequency power spectra that reflect the neurological modulation impairment of motor neurons. The diagnostic value, determination, management suggestions are displayed on the device.

Claims

1. A method for testing a subject for a brain condition comprising at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and chronic traumatic encephalopathy using a portable device, the method comprising:

acquiring, by a processor, electromyogram (EMG) signals of the subject from a detection area of the body using an EMG sensor device operatively coupled to a portable base unit, wherein the detection area of the body includes an area of muscles that are active while the subject is engaging in a physical task and the EMG signals are acquired while the subject engages in the physical task, the physical task comprising at least one of a walking gait cycle and a balance test;

processing, by the processor, the acquired EMG signals using the processor of the base unit and software to transform the EMG signals into EMG power spectra data, wherein the EMG power spectra data is characterized by a frequency spread, and determining quantitative features of the EMG power spectra data using at least one of linear and non-linear algorithms, wherein determining quantitative features comprises determining at least a ratio of a first energy value and a second energy value where the first energy value is obtained from a first frequency range in the EMG power spectra data and the second energy value is obtained from a second frequency range in the EMG power spectra data, wherein each of the first frequency range and the second frequency range comprises at least one of;

(a) approximately 30 Hz, (b) approximately 35 Hz to 70 Hz, (c) approximately 74 Hz to 75 Hz, (d) approximately 79 Hz to 80 Hz (e) approximately 93 Hz to 95 Hz, (f) approximately 60 Hz to 150 Hz, and (g) approximately 160 Hz to 320 Hz, and wherein the first frequency range is different than the second frequency range;

comparing, by the processor, the subject'"'"'s EMG power spectra data and the determined quantitative features against those in at least one database;

determining, by the processor, when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy based on the comparisons;

generating, by the processor, diagnostic information based on the comparison and determination, wherein the diagnostic information comprises at least one of the presence, location, and severity of a brain injury and the quantitative features of the subject; and

displaying, on an interactive screen, at least one of the diagnostic information and the quantitative features.

2. The method according to claim 1, wherein acquiring the EMG signals of the subject includes recording the EMG signals in an area over muscles of the subject that are undergoing sustained contraction at submaximal or maximal level while the subject'"'"'s eyes are open or closed.

3. The method according to claim 1, wherein acquiring the EMG signals of the subject includes recording the EMG signals while the subject is standing on one leg on a flat or tilted surface and maintaining balance without assistance or with assistance while the subject'"'"'s eyes are open and while the subject'"'"'s eyes are closed.

4. The method according to claim 1, wherein acquiring the EMG signals of the subject includes collecting the EMG signals in areas over muscles in the subject'"'"'s extremities, waist, and trunk or over the subject'"'"'s peroneus longus muscle.

5. The method according to claim 1, wherein acquiring the EMG signals of the subject includes recording the EMG signals on muscles from at least one of both limbs and both sides of the subject'"'"'s body.

6. The method according to claim 1, wherein processing the acquired EMG signals includes transforming the acquired EMG signals into the frequency domain to obtain the EMG power spectra data by using at least one frequency transformation algorithm comprising a discrete Fourier transform (DFT), a fast Fourier transformation (FFT), or a Wavelet transformation.

7. The method according to claim 6, wherein the frequency spread of the EMG power spectra is at least 500 Hz, and the quantitative features comprise at least one of computed total power in discrete frequency bandwidths relative power.

8. The method according to claim 1, wherein comparing the quantitative features and the EMG power spectra data of the subject includes comparing the subject'"'"'s quantitative features and the EMG power spectra data with comparison data from a database comprising normative data indicative of normal EMG power spectra data for subjects without brain injuries to determine when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy based on differences between the subject'"'"'s quantitative features and EMG power spectra data and normal EMG power spectra data and quantitative features for subjects without brain injuries in the database.

9. The method according to claim 8, wherein determining when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy further comprises determining an additional quantitative feature comprising when there are signal-strength changes within a prokinetic frequency range which is the second frequency range of about 60-150 Hz of the subject'"'"'s EMG power spectra data based on comparison with the prokinetic frequency range of normal EMG power spectra data associated with subjects without brain injuries in the database.

10. The method according to claim 8, wherein determining when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy further comprises determining an additional quantitative feature comprising when there is reduced signal-strength in the range of at least one of approximately 35-70 Hz, approximately 74-75 Hz, approximately 79-80 Hz, and approximately 93-95 Hz of the subject'"'"'s EMG power spectra data based on comparison with the same ranges in normal EMG power spectra data associated with subjects without brain injuries in the database.

11. The method according to claim 8, wherein determining when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy further comprises determining an additional quantitative feature comprising when there are signal-strength changes in an additional frequency range comprising an antikinetic frequency range that is less than 40 Hz of the subject'"'"'s EMG power spectra data based on comparison with the antikinetic frequency range in normal EMG power spectra data associated with subjects without brain injuries in the database.

12. The method according to claim 8, wherein determining when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy further comprises determining when there are increased signal strength changes in an additional frequency range comprising frequency bandwidths centered around 30 Hz and 160 to 320 Hz of the subject'"'"'s EMG power spectra data based on comparison with the bandwidths centered around 30 Hz and 160 to 320 Hz in normal EMG power spectra data associated with subjects without brain injuries in the database.

13. The method according to claim 1, wherein comparing the EMG power spectra data and the quantitative features of the subject against those in the at least one database includes using comparison data comprised of pre-injury test data on the subject and later test results on the subject or using the subject'"'"'s tests recorded over a time period since a brain injury in order to monitor the recovery process.

14. The method according to claim 1, wherein comparing the EMG power spectra data and the quantitative features of the subject'"'"'s EMG signals includes comparing EMG power spectra data collected from one limb or one side of the subject'"'"'s body against the EMG power spectra data obtained from a contralateral limb or an opposite side of the subject'"'"'s body and using the comparison to diagnose a brain hemisphere specific pathology.

15. The method according to claim 1, wherein determining if the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy includes determining when the subject'"'"'s EMG power spectra data corresponds to the EMG power spectra data in a database with subjects with at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease and chronic traumatic encephalopathy.

24. The method of claim 1, wherein the method further comprises monitoring and evaluate at least one of treatment efficacy, disease progression and recovery of the subject'"'"'s brain condition based on the testing determined from the subject'"'"'s EMG power spectra data.

16. A portable device for diagnosing at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and chronic traumatic encephalopathy in a subject, wherein the portable device comprises:

an electromyogram (EMG) signal sensor device for acquiring EMG signals from a detection area of the body of the subject, wherein the detection area of the body includes an area of muscles that are active while the subject is engaging in a physical task and the EMG signals are acquired while the subject engages in the physical task, the physical task comprising at least one of a walking gait cycle and a balance test;

a portable base unit operatively coupled to the EMG signal sensor device comprising;

a memory unit comprising;

software having instructions for performing the assessment of neuromuscular control of the subject;

at least one database; and

a processor coupled to the memory unit, the processor being configured to;

process the acquired EMG signals to transform the EMG signals into a EMG power spectra data, wherein the EMG power spectra data is characterized by a frequency spread;

determine quantitative features from the EMG power spectra data, wherein determining quantitative features of the EMG power spectra data comprises determining at least a ratio of a first energy value and a second energy value where the first energy value is obtained from a first frequency range in the EMG power spectra data and the second energy value is obtained from a second frequency range in the EMG power spectra data, wherein each of the first frequency range and the second frequency range comprises at least one of;

(a) approximately 30 Hz, (b) approximately 35 Hz to 70 Hz, (c) approximately 74 Hz to 75 Hz, (d) approximately 79 Hz to 80 Hz, (e) approximately 93 Hz to 95 Hz, (f) approximately 60 Hz to 150 Hz and (g) approximately 160 Hz to 320 Hz, and wherein the first frequency range is different than the second frequency range;

compare the subject'"'"'s EMG power spectra data and the determined quantitative features with EMG power spectra data and quantitative features from the at least one database;

determine when the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and chronic traumatic encephalopathy based on the comparison;

generate diagnostic information based on the comparison and determination, wherein the diagnostic information comprises at least one of the presence, location and severity of the brain injury and the quantitative features of the subject; and

an interactive screen that is configured to display at least one of the diagnostic information and the quantitative features.

17. The portable device according to claim 16, wherein the software further comprises instructions for receiving input of identification data for the subject, injury history for the subject, and information pertaining to a Standardized Concussion Assessment Tool (SCAT).

18. The portable device according to claim 16, wherein the at least one database comprises at least one of a normative database and a brain pathological specific database.

19. The portable device according to claim 16, wherein the processor is configured to transform the acquired EMG signals into EMG power spectra data using one of a Fourier Transform, a discrete Fourier transform (DFT), a fast Fourier transformation (FFT), and a Wavelet transformation;

and extract the quantitative features from the EMG power spectra data.

20. The portable device according to claim 19, wherein energy in each frequency in the EMG power spectra data is expressed as a percentage of total power of the EMG power spectra data and the frequency spread of the EMG power spectra data spans at least from 0 to about 500 Hz.

21. The portable device according to claim 16, wherein the at least one database comprises EMG power spectra data and quantitative features from at least one preinjury test data of the subject and baseline data of individuals of comparable age and gender relative to the subject.

22. The portable device according to claim 16, wherein the at least one database comprises EMG power spectra data and quantitative features from at least one post injury test of the subject for evaluation of recovery from mTBI.

25. The portable device of claim 16, wherein the processor is further configured to monitor evaluate at least one of treatment efficacy, disease progression and recovery of the subject'"'"'s brain condition based on the testing determined from the subject'"'"'s EMG power spectra data.

23. A non-transitory computer readable medium comprising a plurality of instructions that are executable on a processor of a portable device for adapting the portable device to implement a method for diagnosing at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and chronic traumatic encephalopathy in a subject, wherein the method comprises:

acquiring electromyogram (EMG) signals of the subject from a detection area of the body using an EMG sensor device operatively coupled to a portable base unit, wherein the detection area of the body includes an area of muscles that are active while the subject is engaging in a physical task and the EMG signals are acquired while the subject engages in the physical task, the physical task comprising at least one of a walking gait cycle and a balance test;

processing the acquired EMG signals using the processor of the base unit and software to transform the EMG signals into EMG power spectra data, wherein the EMG power spectra data is characterized by a frequency spread, and determining quantitative features from the transformed EMG signals using at least one of linear and non-linear algorithms, wherein determining quantitative features comprises determining at least a ratio of a first energy value and a second energy value where the first energy value is obtained from a first frequency range in the EMG power spectra data and the second energy value is obtained from a second frequency range in the EMG power spectra data, wherein each of the first frequency range and the second frequency range comprises at least one of;

(a) approximately 30 Hz, (b) approximately 35 Hz to 70 Hz, (c) approximately 74 Hz to 75 Hz, (d) approximately 79 Hz to 80 Hz (e) approximately 93 Hz to 95 Hz, (f) approximately 60 Hz to 150 Hz, and (g) approximately 160 Hz to 320 Hz, and wherein the first frequency range is different than the second frequency range;

comparing the subject'"'"'s EMG power spectra data and the determined quantitative features against those in at least one database;

determining if the subject has at least one of mild traumatic brain injury (mTBI), Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and chronic traumatic encephalopathy based on the comparison;

generating diagnostic information based on the comparison and determination, wherein the diagnostic information comprises at least one of the presence, location and severity of the brain injury and the quantitative features of the subject; and

displaying, on an interactive screen, at least one of the diagnostic information and the quantitative features.

26. The non-transitory computer readable medium of claim 23, wherein the method further comprises monitoring and evaluate at least one of treatment efficacy, disease progression and recovery of the subject'"'"'s brain condition based on the testing determined from the subject'"'"'s EMG power spectra data.