Apparatus for non-invasive in vivo measurement by raman spectroscopy
First Claim
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1. Apparatus for non-invasive in vivo measurement by Raman spectroscopy of a metabolite present in interstitial fluid in the skin of a subject, the apparatus comprising a light source, optical components defining a light path from said light source to a measurement location at a depth located at from 200 μ
- m to 300 μ
m beneath the surface of the skin, a light detection unit, optical components defining a return path for Raman scattered light from said measurement location to said light detection unit, and a skin engaging member having a distal surface for defining the position of said optical components defining the return path with respect to a surface of said skin in use, and wherein said optical components defining a return path for Raman scattered light selectively transmit to said light detection unit light scattered from near said measurement location of which at least 50% of Raman scattered light received at the light detection unit originates at depths from 60 to 400 μ
m beyond said distal surface of the skin engaging member.
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Abstract
A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector light scattered from the metabolite in interstitial fluid in skin in a measurement location at a depth of from 200-300 μm below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.
17 Citations
18 Claims
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1. Apparatus for non-invasive in vivo measurement by Raman spectroscopy of a metabolite present in interstitial fluid in the skin of a subject, the apparatus comprising a light source, optical components defining a light path from said light source to a measurement location at a depth located at from 200 μ
- m to 300 μ
m beneath the surface of the skin, a light detection unit, optical components defining a return path for Raman scattered light from said measurement location to said light detection unit, and a skin engaging member having a distal surface for defining the position of said optical components defining the return path with respect to a surface of said skin in use, and wherein said optical components defining a return path for Raman scattered light selectively transmit to said light detection unit light scattered from near said measurement location of which at least 50% of Raman scattered light received at the light detection unit originates at depths from 60 to 400 μ
m beyond said distal surface of the skin engaging member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- m to 300 μ
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13. A method for non-invasive in vivo measurement by Raman spectroscopy of a metabolite present in interstitial fluid in the skin of a subject, comprising directing light from a light source into the skin via optical components defining a light path from said light source to a measurement location in the skin at a depth located at from 200 μ
- m to 300 μ
m beneath the surface of the skin, receiving Raman scattered light back from the skin at a light detection unit via optical components defining a return path for Raman scattered light from said measurement location to said light detection unit, whilst using a skin engaging member having a distal surface for defining the position of said optical components defining the return path with respect to a surface of said skin in use, and wherein said optical components defining a return path for Raman scattered light selectively transmit to said light detection unit light scattered from near said measurement location of which at least 50% of Raman scattered light received at the light detection unit originates at depths from 60 to 400 μ
m beyond said distal surface of the skin engaging member and deriving a measurement of said metabolite concentration at said measuring location from the Raman scattered light received at the light detection unit. - View Dependent Claims (14, 15)
- m to 300 μ
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16. A handpiece for use in an apparatus for non-invasive in vivo measurement by Raman spectroscopy of a metabolite present in interstitial fluid in the skin of a subject, the apparatus comprising a light source, optical components defining a light path from said light source to a measurement location at a depth located at from 200 μ
- m to 300 μ
m beneath the surface of the skin, a light detection unit, optical components defining a return path for Raman scattered light from said measurement location to said light detection unit, and a skin engaging member having a distal surface for defining the position of said optical components defining the return path with respect to a surface of said skin in use, and wherein said optical components defining a return path for Raman scattered light selectively transmit to said light detection unit light scattered from near said measurement location of which at least 50% of Raman scattered light received at the light detection unit originates at depths from 60 to 400 μ
m beyond said distal surface of the skin engaging member, said handpiece containing said optical components defining the light path for light received at said handpiece from the light source to communicate said light to the measurement location at said depth. - View Dependent Claims (17, 18)
- m to 300 μ
Specification