Systems and methods for activity level pacing

• US 10,434,317 B2
• Filed: 10/30/2017
• Issued: 10/08/2019
• Est. Priority Date: 10/31/2016
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Huelskamp, Paul, Kane, Michael J., Juffer, Lance Eric
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US15/797,932
• Publication Number:
  US 20180117339A1
• Time in Patent Office: 708 Days
• Field of Search: None
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/37512 Pacemakers
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Systems, devices, and methods for pacing a heart of a patient are disclosed. An illustrative method may include determining a motion level of the patient using a motion sensor of an implantable medical device secured relative to a patient'"'"'s heart, and setting a pacing rate based at least in part on the patient'"'"'s motion level. The patient'"'"'s motion level may be determined by, for example, comparing the motion level sensed by the motion sensor during a current heart beat to a motion level associated with one or more previous heart beats. Noise may occur in the motion level measurements during those heart beats that transition between an intrinsically initiated heart beat and pace initiated heart beat. Various techniques may be applied to the motion level measurements to help reduce the effect of such noise.

Claims

1. An implantable medical device (IMD) implantable within a patient'"'"'s heart, the IMD comprising:

two or more sensors including a motion sensor;

a controller operatively coupled to the two or more sensors, the controller configured to;

identify a plurality of heart beats using one or more of the sensors, each of the plurality of heart beats having a systole phase and diastole phase;

identify each of two or more of the plurality of heart beats as an intrinsically initiated heart beat or a pace initiated heart beat;

for an intrinsically initiated heart beat, identify a motion level of the IMD using the motion sensor, and compare the identified motion level of the IMD to a motion level of the IMD identified for one or more previous intrinsically initiated heart beats, and identify a motion level of the patient based at least in part on the comparison;

for a pace initiated heart beat, identify a motion level of the IMD using the motion sensor, and compare the identified motion level of the IMD to a motion level of the IMD identified for one or more previous pace initiated heart beats, and identify the motion level of the patient based at least in part on the comparison; and

set a pacing rate parameter based at least in part on the identified motion level of the patient.

2. The IMD of claim 1, wherein for an intrinsically initiated heart beat that immediately follows a pace initiated heart beat, the controller is configured to not identify the motion level of the patient based on that heart beat.

3. The IMD of claim 1, wherein for a pace initiated heart beat that immediately follows an intrinsically initiated heart beat, the controller is configured to not update the motion level of the patient based on that heart beat.

4. The IMD of claim 1, wherein for an intrinsically initiated heart beat, the controller is configured to:

compare the identified motion level of the IMD to the motion level of the IMD previously identified for an immediately preceding heart beat if the immediately preceding heart beat was an intrinsically initiated heart beat; and

if the immediately preceding heart beat was a pace initiated heart beat, then either not identify the motion level of the IMD using the motion sensor during the systole phase of the intrinsically initiated heart beat or ignore the identified motion level of the IMD.

5. The IMD of claim 1, wherein for a pace initiated heart beat, the controller is configured to:

compare the identified motion level of the IMD to the motion level of the IMD previously identified for an immediately preceding heart beat if the immediately preceding heart beat was a pace initiated heart beat; and

if the immediately preceding heart beat was an intrinsically initiated heart beat, then either not identify a motion level of the IMD using the motion sensor during the systole phase of the pace initiated heart beat or ignore the identified motion level of the IMD.

6. The IMD of claim 1, wherein the controller is configured to:

for an intrinsically initiated heart beat, compare the identified motion level of the IMD to an average motion level of the IMD that is an average of the motion levels of the IMD identified for two or more previous intrinsically initiated heart beats; and

for a pace initiated heart beat, compare the identified motion level of the IMD to an average motion level of the IMD that is an average of the motion levels of the IMD identified for two or more previous pace initiated heart beats.

7. The IMD of claim 6, wherein:

for an intrinsically initiated heart beat, the average motion level of the IMD is a weighted average; and

for a paced initiated heart beat, the average motion level of the IMD is a weighted average.

8. The IMD of claim 6, wherein the two or more previous intrinsically initiated heart beats and the two or more previous pace initiated heart beats all fall within a moving time window that extends back a predetermined amount of time.

9. The IMD of claim 1, wherein the controller is configured to:

identify a current heart rate of the patient'"'"'s heart;

identify a current heart beat as corresponding to one of two or more heart rate ranges based at least in part on the identified current heart rate;

for an intrinsically initiated heart beat, compare the identified motion level of the IMD to a motion level of the IMD identified for one or more previous intrinsically initiated heart beats that have been identified as corresponding to the same heart rate range, and to identify a motion level of the patient based at least in part on the comparison; and

for a pace initiated heart beat, compare the identified motion level of the IMD to a motion level of the IMD identified for one or more previous pace initiated heart beats that have been identified as corresponding to the same heart rate range, and to identify a motion level of the patient based at least in part on the comparison.

10. The IMD of claim 1, wherein the controller is configured to:

identify each of the plurality of heart beats as an intrinsically initiated heart beat, a pace initiated heart beat or a fusion heart beat; and

wherein for a fusion heart beat, not identify the motion level of the patient based on that heart beat.

11. The IMD of claim 1, wherein the motion sensor comprises a three-axis accelerometer, and another of the two or more sensors comprises two or more electrodes connected to circuitry that is configured to sense electrical signals of the patient'"'"'s heart.

12. The IMD of claim 1, wherein the IMD is a leadless cardiac pacemaker.

13. A method for identifying an activity level of a patient using a motion sensor implanted within the patient'"'"'s heart, the method comprising:

identifying a plurality of heart beats, each of the plurality of heart beats having a systole phase and diastole phase;

identifying each of two or more of the plurality of heart beats as an intrinsically initiated heart beat or a pace initiated heart beat;

for an intrinsically initiated heart beat, identifying a motion level of the IMD using the motion sensor, and comparing the identified motion level of the IMD to a motion level of the IMD identified for one or more previous intrinsically initiated heart beats and identifying the activity level of the patient based at least in part on the comparison; and

for a pace initiated heart beat, identifying a motion level of the IMD using the motion sensor, and comparing the identified motion level of the IMD to a motion level of the IMD identified for one or more previous pace initiated heart beats and identifying the activity level of the patient based at least in part on the comparison.

14. The method of claim 13, wherein for an intrinsically initiated heart beat that immediately follows a pace initiated heart beat, not identifying the activity level of the patient based on that heart beat.

15. The method of claim 13, wherein for a pace initiated heart beat that immediately follows an intrinsically initiated heart beat, not identifying the activity level of the patient based on that heart beat.

16. The method of claim 13, further comprising:

pacing the patient'"'"'s heart at a pacing rate, wherein the pacing rate is based at least in part on the identified activity level of the patient.

17. A leadless cardiac pacemaker (LCP) implantable within a patient'"'"'s heart, the LCP comprising:

a housing;

two or more electrodes secured relative to the housing, the two or more electrodes are configured to sense electrical signals of the patients heart;

an accelerometer situated inside of the housing;

circuitry situated inside of the housing and operatively coupled to the two or more electrodes and the accelerometer, the circuitry is configured to;

identify a plurality of heart beats using the two or more electrodes, each of the plurality of heart beats having a systole phase and diastole phase;

identify each of two or more of the plurality of heart beats as an intrinsically initiated heart beat or a pace initiated heart beat;

for an intrinsically initiated heart beat, identify a motion level of the LCP using the accelerometer during the systole phase of the intrinsically initiated heart beat, and compare the identified motion level of the LCP to a motion level of the LCP identified for one or more previous intrinsically initiated heart beats but not any of the previous pace initiated heart beats, and identify an activity level of the patient based at least in part on the comparison;

pace the patient'"'"'s heart at a pacing rate that is based at least in part on the identified activity level of the patient.

18. The LCP of claim 17, wherein for an intrinsically initiated heart beat that immediately follows a pace initiated heart beat, the circuitry is configured to not identify the activity level of the patient based on that heart beat.

19. The LCP of claim 17, wherein the circuitry is further configured to:

for a pace initiated heart beat, identify a motion level of the LCP using the accelerometer during the systole phase of the pace initiated heart beat, and compare the identified motion level of the LCP to a motion level of the LCP identified for one or more previous pace initiated heart beats but not any of the previous intrinsically initiated heart beats, and identify the activity level of the patient based at least in part on the comparison.

20. The LCP of claim 19, wherein the circuitry is configured to:

for an intrinsically initiated heart beat, compare the identified motion level of the LCP to an average motion level of the LCP that is an average of the motion levels of the LCP identified for two or more previous intrinsically initiated heart beats;

for a pace initiated heart beat, compare the identified motion level of the LCP to an average motion level of the LCP that is an average of the motion levels of the LCP identified for two or more previous pace initiated heart beats; and

the two or more previous intrinsically initiated heart beats and the two or more previous pace initiated heart beats all fall within a moving time window that extends back a predetermined amount of time.