Polyomavirus neutralizing antibodies
First Claim
Patent Images
1. An isolated antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
- (i) a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
186, (b) a HCDR2 of SEQ ID NO;
187, (c) a HCDR3 of SEQ ID NO;
188; and
alight chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
196, (e) a LCDR2 of SEQ ID NO;
197, and (f) a LCDR3 of SEQ ID NO;
198;
or(ii) a heavy chain variable region that comprises;
(a) a HCDR1 of SEQ ID NO;
206, (b) a HCDR2 of SEQ ID NO;
207, (c) a HCDR3 of SEQ ID NO;
208; and
a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
216, (e) a LCDR2 of SEQ ID NO;
217, and (f) a LCDR3 of SEQ ID NO;
218.
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Abstract
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
5 Citations
26 Claims
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1. An isolated antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
- (i) a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
186, (b) a HCDR2 of SEQ ID NO;
187, (c) a HCDR3 of SEQ ID NO;
188; and
alight chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
196, (e) a LCDR2 of SEQ ID NO;
197, and (f) a LCDR3 of SEQ ID NO;
198;
or(ii) a heavy chain variable region that comprises;
(a) a HCDR1 of SEQ ID NO;
206, (b) a HCDR2 of SEQ ID NO;
207, (c) a HCDR3 of SEQ ID NO;
208; and
a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
216, (e) a LCDR2 of SEQ ID NO;
217, and (f) a LCDR3 of SEQ ID NO;
218. - View Dependent Claims (2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
- (i) a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
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3. An isolated antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
-
(i) a heavy chain variable region (vH) that comprises SEQ ID NO;
192, and a light chain variable region (vL) that comprises SEQ ID NO;
202;
or(ii) a heavy chain variable region (vH) that comprises SEQ ID NO;
212, and a light chain variable region (vL) that comprises SEQ ID NO;
222. - View Dependent Claims (4)
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Specification