Improving symmetry in brain scans
First Claim
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1. A method for reducing structural anatomical asymmetry in a brain scan image, comprising:
- obtaining the brain scan image having asymmetry;
adapting a symmetric shape-based model to the brain scan image, wherein the symmetric shape-based brain model represents surfaces of anatomical sub-structures in the brain as an adaptive mesh including a plurality of corresponding vertex pairs, each corresponding vertex pair including corresponding vertices in first and second hemispheres of the brain, to generate an adapted mesh comprising a set of adapted vertex pairs V1, V2;
fitting a mid-plane to the adapted mesh, the mid-plane being positioned and oriented to minimize a sum of a squared distance between the corresponding first and second hemisphere adapted vertex pairs V1, V2; and
computing a patient-specific symmetric anatomical model of the brain by making the corresponding adapted vertices V1 and V2 of the vertex pairs V1, V2 of the adapted mesh symmetric about the mid-plane to generate the patient-specific symmetric anatomical model of the brain with symmetric vertex pairs V1′
and V2′
.
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Abstract
A symmetric model representing anatomical structures of the brain is adapted to a brain scan image with a transform. First and second points provided on first and second hemispheres of the brain image and a patient-specific symmetric anatomical model of the brain is computed based on the transformation.
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Citations
15 Claims
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1. A method for reducing structural anatomical asymmetry in a brain scan image, comprising:
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obtaining the brain scan image having asymmetry; adapting a symmetric shape-based model to the brain scan image, wherein the symmetric shape-based brain model represents surfaces of anatomical sub-structures in the brain as an adaptive mesh including a plurality of corresponding vertex pairs, each corresponding vertex pair including corresponding vertices in first and second hemispheres of the brain, to generate an adapted mesh comprising a set of adapted vertex pairs V1, V2; fitting a mid-plane to the adapted mesh, the mid-plane being positioned and oriented to minimize a sum of a squared distance between the corresponding first and second hemisphere adapted vertex pairs V1, V2; and computing a patient-specific symmetric anatomical model of the brain by making the corresponding adapted vertices V1 and V2 of the vertex pairs V1, V2 of the adapted mesh symmetric about the mid-plane to generate the patient-specific symmetric anatomical model of the brain with symmetric vertex pairs V1′
and V2′
. - View Dependent Claims (2, 3)
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4. A system for reducing structural anatomical asymmetry in a brain scan image obtained of a patient, the system comprising:
a processor configured to; adapt a symmetric shape-based model to a brain scan image, wherein the symmetric shape-based model represents surfaces of anatomical sub-structures in a brain as an adaptive mesh, wherein the symmetric shape-based model comprises a plurality of corresponding vertex pairs; fit a mid-plane to the adapted symmetric shape-based model, the mid-plane being positioned and oriented to minimize a sum of squared distances between the corresponding vertex pairs of the adapted symmetric shape-based model; compute a patient-specific symmetric anatomical model of the brain by making the corresponding vertex pairs of the adapted symmetric shape-based model symmetric about the mid-plane. - View Dependent Claims (5, 6, 7, 8, 9, 10)
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11. A system for reducing structural anatomical asymmetry in a brain scan image of a patient, the system comprising:
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a processor configured to; receive the brain scan image and a symmetric shape-based brain model, the symmetric shape-based brain model representing at least sub-cordical brain structures, adapt the symmetric shape-based brain model to corresponding brain structures of the brain scan image, fit a mid-sagittal plane to the adapted shape-based brain model, based on the adapted shape-based brain model and the first mid-sagittal plane, forming a patient specific brain model, deriving a transform between the patient specific brain model and the symmetric shape-based brain model, with the transform, converting the brain scan image to a symmetric brain image; and a display configured to selectively display the brain scan image and the symmetric brain image; wherein the symmetric shape-based brain model represents surfaces of anatomical substructures in a brain as an adaptive mesh including a plurality of corresponding vertex pairs, the vertices of each pair being disposed in different hemispheres of the brain, and wherein the processor is further configured to fit the mid-sagittal plane to the adapted shape-based brain model by positioning and orienting the mid-sagittal plane to minimize a sum of square distances between the mid-sagittal plane and the corresponding vertex pairs. - View Dependent Claims (12, 13, 14, 15)
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Current AssigneeKoninklijke Philips N.V.
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Original AssigneeKoninklijke Philips N.V.
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InventorsWenzel, Fabian, Moore, Elizabeth Anne, Stehle, Thomas Heiko, Franz, Astrid Ruth, Meyer, Carsten
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Primary Examiner(s)Woldemariam, Aklilu K
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Application NumberUS14/780,247Publication NumberTime in Patent Office2,031 DaysField of Search382128, 324307, 324312, 324318, 342309, 600407, 600425, 600428, 345629US Class CurrentCPC Class CodesA61B 6/501 for diagnosis of the head, ...G06T 2207/30016 BrainG06T 3/18 Image warping, e.g. rearran...G06T 7/0012 Biomedical image inspectionG06T 7/10 Segmentation; Edge detectio...
