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Computer simulation for testing and monitoring of treatment strategies for stress hyperglycemia

  • US 10,438,700 B2
  • Filed: 08/05/2013
  • Issued: 10/08/2019
  • Est. Priority Date: 08/03/2012
  • Status: Active Grant
First Claim
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1. A computer-implemented method for testing of monitoring and/or treatment strategies for patients experiencing stress hyperglycemia, comprising:

  • providing a computer-executable mathematical model of the human glucose-insulin metabolic system and a database of a population of simulated human subjects collectively having a set of metabolic parameters with values encompassing a distribution of observed parameters in subjects not experiencing stress hyperglycemia;

    adding a time-varying coefficient representing collective action of stress hormones on hepatic glucose production (HGP) and peripheral glucose uptake (PGU), into said model at points modeling action of HGP and PGU, to obtain a modified model;

    obtaining a time-series of simulated blood glucose (BG) values for said population of simulated subjects using said model;

    fitting said time-varying coefficient to said simulated BG values such that said simulated BG values replicate real BG values obtained from actual stress hyperglycemia patients to obtain a set of time-varying coefficient vectors;

    correlating time-varying coefficient vectors and virtual subject data with real patient data to obtain stress action profiles;

    determining effects of said stress hormones on stress hyperglycemia by applying various combinations of stress action profiles and virtual population data in said modified model in a computer processor;

    identifying a treatment protocol for a patient experiencing stress hyperglycemia by comparing a stress action profile of said patient with said obtained stress action profiles; and

    treating said patient for effects of stress hyperglycemia with a treatment protocol associated with an obtained stress action profile corresponding to the stress action profile of said patient.

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