Microcapsules comprising lutein or lutein ester

• US 10,440,983 B2
• Filed: 02/08/2016
• Issued: 10/15/2019
• Est. Priority Date: 02/06/2015
• Status: Active Grant

• Current Assignee: BASF SE
• Original Assignee: BASF SE
• Inventors: Musaeus, Nina, Krylbo, Inge-Lise
• Primary Examiner(s): Vu, Jake M
• Application Number:
  US15/549,028
• Publication Number:
  US 20180027865A1
• Time in Patent Office: 1,345 Days
• Field of Search: None
• CPC Class Codes: A23L 29/284 Gelatin; Collagen
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/155 Vitamins A or D
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A23P 10/30 Encapsulation of particles, e.g. foodstuff additives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/224 Encapsulating agent
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/5432 Gelatine
• CPC Class Codes: A61K 31/015 carbocyclic
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/23 of acids having a carboxyl group bound to a chain of seven or more carbon atoms
• CPC Class Codes: A61K 9/146 with organic macromolecular compounds
• CPC Class Codes: A61K 9/1676 having a drug-free core with discrete complete coating layer containing drug adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921
• CPC Class Codes: A61K 9/5057 Gelatin
• CPC Class Codes: A61K 9/5063 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/5015
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals

Abstract

The invention relates to a microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising fish gelatine and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier.

The invention further relates to a process of preparing the microcapsule as well as uses and products comprising the microcapsule.

Claims

1. A microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising a low fish bloom gelatin having a strength of 80 bloom or less as the sole agent with dispersing properties present, and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier.

2. The microcapsule according to claim 1, wherein the content of said at least one active substance calculated as free lutein is from 1 to 20% of total weight of the microcapsule.

3. The microcapsule according to claims 1, wherein the content of said at least one active substance calculated as free lutein is from 3 to 15% of total weight of the microcapsule.

4. The microcapsule according to claim 1, wherein the content of said at least one active substance calculated as free lutein is from 4 to 13% of total weight of the microcapsule.

5. The microcapsule according to claim 1, wherein the content of said at least one active substance calculated as free lutein is from 5 to 10% of total weight of the microcapsule.

6. The microcapsule according to claim 1 further comprising at least one antioxidant and/or plasticizer.

7. The microcapsule according to claim 1, wherein said fish gelatin is a fish gelatine having a strength of 30 bloom or less.

8. The microcapsule according to claim 1, wherein said fish gelatin is a fish gelatine having a strength of zero bloom.

9. The microcapsule according to claim 1 prepared from an emulsion of melted or dissolved lutein or lutein ester concentrate in an aqueous solution of said fish gelatine in the absence of an emulsifier, wherein said lutein or lutein ester concentrate(s) is optionally melted or dissolved in an edible oil.

10. A process of preparing the microcapsule according to claim 1, which process comprises the steps of

melting or dissolving lutein or lutein ester concentrate(s),

providing an aqueous solution of said fish gelatine having a strength of 80bloom or less as the sole agent with dispersing properties present, and said optionally other matrix components,

mixing said aqueous solution and said melted or dissolved lutein or lutein ester concentrate(s),

homogenizing the resulting preparation without addition of an emulsifier,

finely dividing and drying the mixture thus obtained to prepare a mass of particles each containing lutein or lutein ester(s) embedded in said fish gelatine.

11. The process according to claim 10, wherein the lutein ester concentrate(s) is melted or dissolved in edible oil, selected from the group consisting of sunflower oil, olive oil, cotton seed oil, safflower oil, MCT oil, palm oil and hydrogenated palm oil.

12. The process according to claim 10, wherein said aqueous solution of fish gelatin is added to said melted or dissolved lutein or lutein ester concentrate(s) before homogenization.

13. The process according to claim 10, wherein said melted or dissolved lutein or lutein ester concentrate(s) is added to said aqueous solution of fish gelatine before homogenization.

14. The process according to claim 10, comprising a further step of homogenization.

16. A product comprising the microcapsule according to claim 1.

17. The product according to claim 16, wherein the product is a tablet, a food, a food supplement, a beverage, a dairy, a pharmaceutical or veterinary product, a feed or feed supplement, a personal care products or a household product.

18. The product according to claim 16, wherein said product being selected from the group consisting of tablet, dairy and beverage and said fish gelatine is present and has a strength of 30 bloom or less.

19. The microcapsule according to claim 1, wherein said fish gelatin is a fish gelatine having a strength of 50 bloom or less.

15. A microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising low boom fish gelatine having a strength of 80 bloom or less as the sole agent with dispersing properties present, and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier obtainable by a process comprising the steps of

melting or dissolving lutein or lutein ester concentrate(s),

providing an aqueous solution of said low bloom fish gelatine and said optionally other matrix components,

mixing said aqueous solution and said melted or dissolved lutein or lutein ester concentrate(s),

homogenizing the resulting preparation without addition of an emulsifier,

finely dividing and drying the mixture thus obtained to prepare a mass of particles each containing lutein or lutein ester(s) embedded in said fish gelatine.

20. A microcapsule consisting essentially of at least one active substance selected from lutein and lutein esters embedded in a matrix consisting essentially of a low fish bloom gelatin having a strength of 80 bloom or less and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier.