Method and system for characterizing cardiovascular systems from single channel data
First Claim
1. A method for detecting a cardiac dysfunction using a computing device, comprising:
- receiving only one-dimensional electrophysiological data;
constructing multi-dimensional electrophysiological data from the only one-dimensional electrophysiological data;
defining a phase space system from the multi-dimensional electrophysiological data;
detecting the cardiac dysfunction from the phase space system; and
providing an indicator of the cardiac dysfunction.
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Accused Products
Abstract
Methods to identify and risk stratify disease states, cardiac structural defects, functional cardiac deficiencies induced by teratogens and other toxic agents, pathological substrates, conduction delays and defects, and ejection fraction using single channel biological data obtained from the subject. A modified Matching Pursuit (MP) algorithm may be used to find a noiseless model of the data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to characterize the cardiac system. In another method, space-time domain is divided into a number of regions (which is largely determined by the signal length), the density of the signal is computed in each region and input to a learning algorithm to associate them to the desired cardiac dysfunction indicator target.
10 Citations
20 Claims
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1. A method for detecting a cardiac dysfunction using a computing device, comprising:
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receiving only one-dimensional electrophysiological data; constructing multi-dimensional electrophysiological data from the only one-dimensional electrophysiological data; defining a phase space system from the multi-dimensional electrophysiological data; detecting the cardiac dysfunction from the phase space system; and providing an indicator of the cardiac dysfunction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for detecting a cardiac dysfunction using a computing device, comprising:
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receiving only one-dimensional electrophysiological data; constructing multi-dimensional electrophysiological data from the only one-dimensional electrophysiological data; defining a phase space system from the multi-dimensional electrophysiological data; determining by a baseline measurement of a subject'"'"'s physiological condition from the phase space system; determining a first risk score associated with the baseline measurement of the subject'"'"'s physiological condition; applying a therapy to the subject and subsequently receiving only second one-dimensional electrophysiological data;
constructing second multi-dimensional electrophysiological data from the only second one-dimensional electrophysiological data;
defining a second phase space system from the second multi-dimensional electrophysiological data;determining a second measurement of the subject'"'"'s physiological condition from the second phase space system after the therapy is applied; determining a second risk score associated with the second measurement of the subject'"'"'s physiological condition; and comparing the first risk score and the second risk score to determine a utility of patient therapies.
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14. A non-transitory computer readable medium having computer readable instructions stored thereon that when executed by a computing device causes the computing device to perform a method for detecting a cardiac dysfunction, the method comprising:
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receiving only one-dimensional electrophysiological data; constructing multi-dimensional electrophysiological data from the only one-dimensional electrophysiological data; defining a phase space system from the multi-dimensional electrophysiological data; detecting the cardiac dysfunction from the phase space system; and providing an indicator of the cardiac dysfunction. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification