Stabilization of vertebral bodies with bone particle slurry

• US 10,441,336 B2
• Filed: 06/24/2018
• Issued: 10/15/2019
• Est. Priority Date: 06/14/2017
• Status: Active Grant

• Current Assignee: Osteoagra LLC
• Original Assignee: Osteoagra LLC
• Inventors: Alleyne, Neville
• Primary Examiner(s): Bates, David W
• Application Number:
  US16/016,635
• Publication Number:
  US 20180360513A1
• Time in Patent Office: 478 Days
• CPC Class Codes: A61B 17/8805 for introducing fluid filler into bone or extracting it A61B17/7097, A61B17/8833 take precedence
• CPC Class Codes: A61B 17/8816 characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
• CPC Class Codes: A61B 17/8822 characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
• CPC Class Codes: A61B 17/8827 with filtering, degassing, venting or pressure relief means
• CPC Class Codes: A61B 17/8833 Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
• CPC Class Codes: A61B 2017/8838 for mixing bone cement or fluid fillers
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2/30723 Plugs or restrictors for sealing a cement-receiving space tools for inserting plugs A61F2/4614; sealing collars for use during cementing A61B17/8808
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2310/00359 Bone or bony tissue
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/38 for reconstruction of the spine, vertebrae or intervertebral discs
• CPC Class Codes: A61L 27/025 Other specific inorganic materials not covered by A61L27/04 - A61L27/12
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 : Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 : Materials at least partially resorbable by the body

Abstract

A medical implant comprises a slurry of bone particles that are injected into a vertebral body under pressure. The liquid component of the slurry may be aspirated while the slurry is being injected so that the bone particles of the slurry pack into the central area of the vertebral body to provide structural support. The injected slurry may be agitated during the procedure to maximize the structural strength of the implant after the procedure.

Claims

1. A method of structurally supporting a vertebral body comprising:

forming one or more openings to a central portion of a vertebral body and placing a cannula through a first opening of the one or more openings;

injecting a slurry of bone particles through the cannula, wherein the slurry of bone particles consists essentially of bone particles, water, and optionally one or more additional ingredients selected from salts, growth factor, blood, platelets, contrast agent, stem cells, antibiotics, chemotherapeutic agents, bisphosphonates, and osteoporosis therapy drugs,

pressurizing the slurry during and/or after the injecting to force bone particles of the slurry into direct contact with bone tissue inside the vertebral body.

2. The method of claim 1 comprising:

inserting a catheter into the central portion of the vertebral body through the cannula;

injecting the slurry of bone particles through the catheter.

3. The method of claim 1 comprising:

removing the cannula; and

inserting a plug into the first opening.

4. The method of claim 1, comprising aspirating liquid from the central portion of the vertebral body.

5. The method of claim 1, comprising agitating the slurry in the vertebral body during the injecting.

6. The method of claim 1, comprising forming at least a second opening to the central portion of the vertebral body.

7. The method of claim 6, comprising

placing a second cannula through the second opening of the one or more openings;

injecting a slurry of bone particles through the second cannula at the same time as injecting a slurry of bone particles through the first cannula.

8. The method of claim 6, comprising:

placing a second cannula through the second opening of the one or more openings;

aspirating liquid from the central portion of the vertebral body through the second cannula while injecting the slurry of bone particles through the first cannula.

9. A method of structurally supporting a vertebral body comprising:

forming one or more openings to a central portion of a vertebral body and placing a cannula through a first opening of the one or more openings;

injecting a slurry of bone particles through the cannula, wherein the slurry of bone particles is 20 to 85 percent bone by volume, and

pressurizing the slurry during and/or after the injecting to force bone particles of the slurry into direct contact with bone tissue inside the vertebral body.

10. The method of claim 9, wherein at least 90% of the bone particles are non-demineralized cortical bone particles.