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Method of producing transdermal absorption sheet

  • US 10,441,532 B2
  • Filed: 05/22/2017
  • Issued: 10/15/2019
  • Est. Priority Date: 05/23/2016
  • Status: Active Grant
First Claim
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1. A method of producing a transdermal absorption sheet comprising, in this order:

  • a polymer solution filling step of filling needle-like recessed portions on a mold having the needle-like recessed portions arranged two-dimensionally with a polymer solution;

    a polymer solution drying step of drying the polymer solution filling the needle-like recessed portions to form a polymer layer; and

    a peeling-off step of peeling off the polymer layer from the mold,wherein in the polymer solution drying step, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, andwhen a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, the constant drying rate is set to be lower than a maximum value of a constant drying rate under drying conditions in a concentration range in which the average solid content concentration of the polymer solution is less than 70 wt % and also set to be lower than a maximum value of a constant drying rate under drying conditions in a concentration range in which the average solid content concentration of the polymer solution is more than 80 wt % in terms of weight percent, andwherein the constant drying rate of water under the low rate drying conditions in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent is 0.10 kg/(h·

    m2) or less.

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