Methods for treating pulmonary hypertension

• US 10,441,590 B2
• Filed: 07/07/2017
• Issued: 10/15/2019
• Est. Priority Date: 01/12/2015
• Status: Active Grant

• Current Assignee: Reviva Pharmaceuticals, Inc.
• Original Assignee: Reviva Pharmaceuticals, Inc.
• Inventors: Bhat, Laxminarayan, Cantillon, Marc, Wallis, Ellen M., Bhat, Seema Rani
• Primary Examiner(s): Heyer, Dennis
• Application Number:
  US15/643,630
• Publication Number:
  US 20180125851A1
• Time in Patent Office: 830 Days
• Field of Search: None
• CPC Class Codes: A61K 31/538 ortho- or peri-condensed with carbocyclic ring systems
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 9/12 Antihypertensives

Abstract

The present invention provides a method of using arylpiperazine derivatives for treating pulmonary hypertension. The method comprises a step of administering to a patient in need thereof an effective amount of a compound of Formula 1, which is an arylpiperazine derivative.

Claims

1. A method of treating pulmonary hypertension in a subject, the method comprising administering to a subject suffering from pulmonary hypertension an effective amount of a compound of:

2. The method according to claim 1, wherein the compound is in the form of a hydrochloride salt.

3. The method according to claim 1, wherein the compound is administered in a pharmaceutical composition comprising a pharmaceutically acceptable carrier, excipient, or diluent.

4. The method according to claim 1, wherein the compound is orally administered.

5. The method according to claim 1, which treats pulmonary arterial hypertension.

6. The method according to claim 1, which treats pulmonary hypertension in a subject with chronic obstructive pulmonary disease (COPD).

7. The method according to claim 1, which treats pulmonary hypertension in a subject with sickle cell disease.

8. The method according to claim 1, which treats pulmonary hypertension in a subject with human immunodeficiency virus (HIV).

9. The method according to claim 1, which further treats depression in the subject.

10. The method according to claim 1, which further treats anxiety in the subject.