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Methods and systems for inhibiting vascular inflammation

  • US 10,441,747 B2
  • Filed: 01/26/2015
  • Issued: 10/15/2019
  • Est. Priority Date: 01/22/2002
  • Status: Expired due to Term
First Claim
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1. A method for inhibiting inflammation in a patient'"'"'s vasculature, said method comprising:

  • positioning a catheter within a lumen of a blood vessel of the patient, the blood vessel having had a revascularization procedure performed thereon;

    advancing a needle radially outwardly from the catheter through a wall of the blood vessel and into an adventitial tissue surrounding the blood vessel; and

    delivering an anti-inflammatory agent into the adventitial tissue and a perivascular tissue through the needle advanced into the adventitial tissue in an amount sufficient to inhibit inflammation of the blood vessel after the revascularization procedure, wherein the anti-inflammatory agent consists essentially of dexamethasone or dexamethasone phosphate,wherein the inhibition or a reduction of inflammation is characterized by a detectable lack of a significant increase or a detectable reduction, respectively, in monocyte chemotractive protein-1 (MCP-1) levels in circulating blood.

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