Jig for microneedle array placement and microneedle array device

• US 10,441,767 B2
• Filed: 10/27/2011
• Issued: 10/15/2019
• Est. Priority Date: 10/27/2010
• Status: Active Grant

• Current Assignee: ASTI Corporation
• Original Assignee: ASTI Corporation
• Inventors: Tamaru, Takuya, Nonaka, Isamu, Wada, Yuko
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Lee, Weng
• Application Number:
  US13/880,714
• Publication Number:
  US 20130218084A1
• Time in Patent Office: 2,910 Days
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

The invention relates to a jig for microneedle array placement that is provided with a main jig body with through holes through which the microneedles of the microneedle array will pass and a guiding part that guides the microneedle array to be incorporated into the main jig body and leads the microneedles into the through holes, and a microneedle array device using the jig for microneedle array placement. The invention prevents the deformation of the skin surface during puncture and allows penetration of the microneedles to the prescribed depth under the skin.

Claims

1. A microneedle array device, comprising:

a microneedle array provided with a plurality of microneedle units, aligned in parallel such that each of the microneedle units includes a plurality of microneedles disposed in an array in a straight line;

a main jig body provided with a plurality of through holes for penetration of said microneedles; and

a guiding part for guiding said microneedle array incorporated in said main jig body, so that said microneedles are lead to said through holes,

wherein said each of the microneedle units includes a bonded structure of a pair of divisional elements halved in a longitudinal direction of said each of the microneedle units, the divisional elements including grooves disposed on the divisional elements, such that boundaries of solution channels are formed within the grooves with bonding the pair of divisional elements that face each other.

2. The microneedle array device as claimed in claim 1, wherein said main jig body is provided with microneedle array holders for holding said microneedle array incorporated in said main jig body.

3. The microneedle array device as claimed in claim 2, wherein said microneedle array holders comprise latches placed to be opposing to each other in said main jig body.

4. The microneedle array device as claimed in claim 3, wherein said main jig body is provided with microneedle array holders provided with belt connecting holes for connecting fastening belts.

5. The microneedle array device as claimed in claim 1, wherein said microneedle array comprises a plurality of microneedle units held by a needle holder, in a state of being sandwiched and fixed between an upper case, and a lower ease including a medicinal solution inlet.

6. The microneedle array device as claimed in claim 5, wherein said upper case includes the grooves formed for guiding both ends of said microneedle units.

7. The microneedle array device as claimed in claim 6, wherein said microneedle units are provided with flow channel bosses, and are fixed by inserting said flow channel bosses into through holes formed in said needle holder.

8. The microneedle array device as claimed in claim 7, wherein said lower case is provided with a plurality of projections for preventing deformation of said needle holder, and spaces between said plurality of projections serve as flow channels.

9. The microneedle array device as claimed in claim 1, further comprising:

a release paper sticking to an adhering part in a non-use state, and in a using state, said adhering part in a state of blocking said through holes of said main jig body is exposed by releasing of said release paper.

10. The microneedle array device as claimed in claim 5, wherein said needle holder holds said microneedle units in a plurality of arrays.

11. The microneedle array device as claimed in claim 5, wherein said needle holder includes an elastic body.

12. The microneedle array device as claimed in claim 5, wherein said upper case is provided with a stage part, and

wherein said main jig body includes a two-stage engagement part, comprising a projection part which is engaged with said stage part in a non-use state for protecting tips of the microneedles by prohibiting puncturing, and another projection part which is engaged with said stage part in a puncturing state for maintaining the puncturing state during puncturing.

13. The microneedle array device as claimed in claim 1, wherein said microneedle array is configured such that, in a state that said microneedle array is engaged with the through holes and is pushed, each of said microneedles breaks through an adhering part.

14. The microneedle array device as claimed in claim 1, wherein said microneedle array is configured such that, in a state that said microneedle array is engaged with the through holes and is pushed, each of said microneedles penetrates into a surface of said main jig body.

15. The microneedle array device as claimed in claim 1, wherein said microneedle array is configured such that each of said microneedles breaks through an adhering part and penetrates into a surface of said main jig body.

16. The microneedle array device as claimed in claim 1, further comprising:

a release paper sticking to an adhering part,

wherein, when said release paper is released, said adhering part is exposed.

17. The microneedle array device as claimed in claim 1, wherein said main jig body includes a two-stage engagement part for a non-use state and for a puncturing state.

18. The microneedle array device as claimed in claim 1, wherein an adhering part is provided on a surface of said main jig body, in a state that said adhering part blocks said through holes, and said adhering part is penetrated by said microneedles in a using state.