Arrays for longitudinal delivery of TTFields to a body

• US 10,441,776 B2
• Filed: 06/29/2017
• Issued: 10/15/2019
• Est. Priority Date: 06/30/2016
• Status: Active Grant

• Current Assignee: Novocure GmbH (NovoCure Limited)
• Original Assignee: Novocure GmbH (NovoCure Limited)
• Inventors: Kirson, Eilon, Wasserman, Yoram, Hershkovich, Hadas Sara, Bomzon, Zeev
• Primary Examiner(s): Fairchild, Mallika D
• Application Number:
  US15/636,722
• Publication Number:
  US 20180001078A1
• Time in Patent Office: 838 Days
• CPC Class Codes: A61B 2018/00059 Material properties
• CPC Class Codes: A61B 2018/00636 Sensing and controlling the application of energy
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61N 1/0408 Use-related aspects
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0484 Garment electrodes worn by the patient
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/321 Electromedical belts
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

Tumors in portions of a subject'"'"'s body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Claims

1. A method of treating a target region in a subject'"'"'s body with tumor treating fields, the target region being located in a portion of the subject'"'"'s body that has a longitudinal axis, the method comprising:

affixing a first plurality of electrodes to the subject'"'"'s body so as to surround a first part of the subject'"'"'s body at a position that is longitudinally prior to the target region;

affixing a second plurality of electrodes to the subject'"'"'s body so as to surround a second part of the subject'"'"'s body at a position that is longitudinally subsequent to the target region; and

applying a first AC voltage with a frequency of 100-500 kHz between all the electrodes in the first plurality of electrodes and all the electrodes in the second plurality of electrodes so as to impose a first AC electric field with field lines that run through the target region longitudinally, wherein the first AC electric field has a field strength of at least 1 V/cm in at least a portion of the target region.

2. The method of claim 1, wherein each of the first and second pluralities of electrodes is capacitively coupled to the subject'"'"'s body.

3. The method of claim 1, further comprising:

affixing a third plurality of electrodes to the subject'"'"'s body on a first side of the target region, at a position that is longitudinally between the first plurality of electrodes and the second plurality of electrodes;

affixing a fourth plurality of electrodes to the subject'"'"'s body on a second side of the target region that is opposite to the first side, at a position that is longitudinally between the first plurality of electrodes and the second plurality of electrodes; and

applying a second AC voltage with a frequency of 100-500 kHz between all the electrodes in the third plurality of electrodes and all the electrodes in the fourth plurality of electrodes so as to impose a second AC electric field through the target region, wherein the second AC electric field has a field strength of at least 1 V/cm in at least a portion of the target region.

4. The method of claim 3, wherein each of the first, second, third, and fourth pluralities of electrodes is capacitively coupled to the subject'"'"'s body.

5. The method of claim 4, wherein each of the first and second AC voltages has a frequency of 125-250 kHz.

6. The method of claim 5, wherein the steps of applying the first AC voltage and applying the second AC voltage are repeated at least 10,000 times in an alternating sequence.

7. The method of claim 3, further comprising:

affixing a fifth plurality of electrodes to the subject'"'"'s body on a third side of the target region, at a position that is longitudinally between the first plurality of electrodes and the second plurality of electrodes;

affixing a sixth plurality of electrodes to the subject'"'"'s body on a fourth side of the target region that is opposite to the third side, at a position that is longitudinally between the first plurality of electrodes and the second plurality of electrodes; and

applying a third AC voltage with a frequency of 100-500 kHz between all the electrodes in the fifth plurality of electrodes and all the electrodes in the sixth plurality of electrodes so as to impose a third AC electric field through the target region, wherein the third AC electric field has a field strength of at least 1 V/cm in at least a portion of the target region.

8. The method of claim 1, wherein the first plurality of electrodes comprises a first plurality of flat electrode elements distributed around the first part of the subject'"'"'s body, and

wherein the second plurality of electrodes comprises a second plurality of flat electrode elements distributed around the second part of the subject'"'"'s body.

9. The method of claim 1, wherein the target region is located in a torso of the subject'"'"'s body, wherein the first plurality of electrodes is positioned around the subject'"'"'s torso below the target region, and wherein the second plurality of electrodes is positioned around the subject'"'"'s torso above the target region.

10. The method of claim 1, wherein the subject has a neck, wherein the target region is located in a torso of the subject'"'"'s body, wherein the first plurality of electrodes is positioned around the subject'"'"'s torso below the target region, and wherein the second plurality of electrodes is positioned around the subject'"'"'s neck.

11. The method of claim 1, wherein the subject has a head and a neck, wherein the target region is located in the subject'"'"'s head, wherein the first plurality of electrodes is positioned around the subject'"'"'s neck, and wherein the second plurality of electrodes is positioned around the subject'"'"'s head.

12. The method of claim 1, wherein the target region is located in a limb of the subject'"'"'s body, wherein the longitudinal axis runs through the limb in a proximal to distal direction, wherein the first plurality of electrodes is positioned around the limb at a position proximal to the target region, and wherein the second plurality of electrodes is positioned around the limb at a position distal to the target region.

13. The method of claim 1, wherein all the electrodes in the first plurality of electrodes are wired in parallel, and wherein all the electrodes in the second plurality of electrodes are wired in parallel.