Controlled stimulation delivery from neurostimulator

• US 10,441,803 B2
• Filed: 08/02/2016
• Issued: 10/15/2019
• Est. Priority Date: 11/13/2011
• Status: Active Grant

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: Towe, Bruce C., Gulick, Daniel
• Primary Examiner(s): Malamud, Deborah L
• Application Number:
  US15/226,775
• Publication Number:
  US 20170056676A1
• Time in Patent Office: 1,169 Days
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: A61N 5/045 specially adapted for treatment inside the body

Abstract

A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.

Claims

1. A system for stimulating an electrode configured to deliver an electrical stimulation to tissue of a subject, comprising:

an implantable device, the implantable device including;

an energy acquisition device configured to wirelessly receive an excitation signal;

a voltage limiting device connected to the energy acquisition device; and

an electrode connected to the voltage limiting device, wherein an electrical output delivered by the electrode to tissue of the subject is limited to a predetermined value by the voltage limiting device, and wherein the electrical output delivered by the electrode is powered by energy from the excitation signal; and

an exciter that is physically unconnected to the energy acquisition device and configured to radiate a wireless pulse width modulated excitation signal to the energy acquisition device of the implantable device, wherein the pulse width modulated excitation signal controls the amount of wireless current delivery to the energy acquisition device.

2. The system of claim 1, wherein the energy acquisition device includes at least one of a dipole antenna and a piezoelectric material.

3. The system of claim 1, wherein the exciter includes at least one of a radio frequency transmitter, an ultrasound emitter, and a photic energy emitter.

4. The system of claim 1, wherein the excitation signal includes a plurality of neurostimulation pulses having a duration of approximately 50 microseconds, each neurostimulation pulse including a plurality of subpulses, each subpulse having a duration of approximately 5 microseconds to 10 microseconds.

5. The system of claim 1, wherein the pulse width modulated signal has a magnitude selected to cause the implantable device to enter a voltage saturation state.

6. The system of claim 5, wherein the pulse width modulated signal has a magnitude selected to cause the implantable device to enter a voltage saturation state when a duty cycle of the excitation signal is approximately 100%.

7. The system of claim 1, wherein the pulse width modulated signal comprises an ultrasound frequency or radio frequency signal that is modulated on and off to define a duty cycle.

8. An implantable device for delivering an electrical stimulation to tissue of a subject, comprising:

an energy acquisition device configured to wirelessly receive a pulse width modulated excitation signal and generate an output voltage using wireless energy received from the pulse width modulation excitation signal;

a voltage limiting device connected to the energy acquisition device, the voltage limiting device being configured to control the amount of energy delivered by the implantable device; and

an electrode connected to the voltage limiting device and configured to deliver the electrical stimulation to tissue of the subject.

9. The implantable device of claim 8, wherein the voltage limiting device includes at least one of a Zener diode, a silicon diode, and a metal oxide varistor.

10. The implantable device of claim 8, wherein the energy acquisition device includes at least one of a dipole antenna and a piezoelectric material.

11. The implantable device of claim 8, wherein the excitation signal includes a plurality of neurostimulation pulses having a duration of approximately 50 microseconds, each neurostimulation pulse including a plurality of subpulses, each subpulse having a duration of approximately 5 microseconds to 10 microseconds.

12. The implantable device of claim 8, wherein the pulse width modulated signal has a magnitude selected to cause the implantable device to enter a voltage saturation state.

13. The implantable device of claim 12, wherein the pulse width modulated signal has a magnitude selected to cause the implantable device to enter a voltage saturation state when a duty cycle of the excitation signal is approximately 100%.

14. The implantable device of claim 8 wherein the pulse width modulated excitation signal comprises an ultrasound frequency or radio frequency signal that is modulated on and off to define a duty cycle.

15. A method of stimulating an electrode configured to deliver an electrical stimulation to tissue of a subject, comprising:

placing an exciter in spatial proximity to an implantable device, the implantable device including;

an energy acquisition device that is physically unconnected to the exciter and is configured to wirelessly receive a pulse width modulated excitation signal from the exciter;

a voltage limiting device connected to the energy acquisition device;

an electrode connected to the voltage limiting device; and

providing instructions to the exciter to radiate a wireless pulse-width modulated output excitation signal directed at the implantable device, wherein the pulse width modulated excitation signal provides wireless energy from the exciter to the energy acquisition device for output by the electrode and has a magnitude selected to cause the voltage limiting device to enter a voltage saturation state.

16. The method of claim 15, wherein the exciter includes at least one of a radio frequency transmitter, an ultrasound emitter, and a photic energy emitter.

17. The method of claim 15, wherein the excitation signal includes a plurality of neurostimulation pulses having a duration of approximately 50 microseconds, each neurostimulation pulse including a plurality of subpulses, each subpulse having a duration of approximately 5 microseconds to 10 microseconds.

18. The method of claim 15, wherein the pulse-width modulated output excitation signal has a magnitude selected to cause the implantable device to enter a voltage saturation state when a duty cycle of the excitation signal is approximately 100%.

19. The method of claim 15 wherein the pulse width modulated excitation signal comprises an ultrasound frequency or radio frequency signal that is modulated on and off to define a duty cycle.