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Compositions and methods for targeted immunomodulatory antibodies and fusion proteins

  • US 10,442,860 B2
  • Filed: 11/28/2016
  • Issued: 10/15/2019
  • Est. Priority Date: 03/05/2010
  • Status: Active Grant
First Claim
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1. An isolated molecule comprising:

  • (a) a targeting moiety that is a polypeptide that specifically binds Interleukin-6 Receptor (IL6R); and

    (b) an immunomodulatory moiety comprising an amino acid sequence of the extracellular domain of Transforming growth factor-beta receptor (TGFβ

    R) or a fragment thereof, wherein the immunomodulatory moiety comprises an amino acid sequence of the extracellular domain of Transforming growth factor-beta receptor selected from the group consisting of SEQ ID NO;

    79-91 or fragment thereof.

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