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Diagnostic devices, systems, and methods

  • US 10,444,232 B2
  • Filed: 08/13/2015
  • Issued: 10/15/2019
  • Est. Priority Date: 08/13/2014
  • Status: Active Grant
First Claim
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1. A handheld diagnostic system, comprising:

  • a reagent cassette comprising a microfluidic network having an inlet, an outlet, and a detection region, the detection region including at least one detection zone; and

    a diagnostic dongle comprising a recess, a manually-actuated pressure system configured to generate negative pressure and store the negative pressure in a pressure chamber, at least one light source, at least one photodetector, a control module, and an input/output connector; and

    a smartphone or personal digital assistant (PDA) coupled to the input/output connector of the diagnostic dongle and configured to provide electrical power to the diagnostic dongle and to transmit data from the diagnostic dongle;

    wherein the at least one detection zone is aligned with a respective photodetector when the reagent cassette is inserted into the recess of the diagnostic dongle;

    wherein the manually-actuated pressure system is configured to apply the negative pressure to the microfluidic network of the reagent cassette to move fluids therethrough;

    wherein the reagent cassette includes reagents and/or a lysis agent for whole blood; and

    wherein the control module is programmed to control the at least one light source and the at least one photodetector to interrogate the respective detection zone to perform at least one of a colorimetric assay, an immunoassay, an electrochemical assay, and absorbance detection.

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