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Composition with high antimicrobial activity and low toxicity

  • US 10,448,634 B2
  • Filed: 04/22/2015
  • Issued: 10/22/2019
  • Est. Priority Date: 08/23/2010
  • Status: Active Grant
First Claim
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1. A method for promoting hemostasis comprising applying a hemostatic composition comprising:

  • at least one species of synthetic copolypeptide of at least forty amino acid residues comprising;

    at least one hydrophilic segment containing at least five contiguous cationic amino acid residues; and

    at least one hydrophobic segment containing at least five contiguous hydrophobic amino acid residues;

    wherein the hydrophilic segment contains a larger number of amino acid residues than the hydrophobic segment;

    wherein said at least one species of synthetic copolypeptide forms multimeric structures in aqueous media;

    wherein said at least one species of synthetic copolypeptide promotes platelet aggregation; and

    wherein the composition promotes hemostasis.

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