Sensor systems

• US 10,448,895 B2
• Filed: 03/11/2014
• Issued: 10/22/2019
• Est. Priority Date: 03/11/2013
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Tathireddy, Prashant, Mastrangelo, Carlos, Solzbacher, Florian, Marrouche, Nassir, Magda, Jules
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/774,070
• Publication Number:
  US 20160015323A1
• Time in Patent Office: 2,051 Days
• Field of Search: None
• CPC Class Codes: A61B 2562/0223 Magnetic field sensors
• CPC Class Codes: A61B 2562/0285 Nanoscale sensors
• CPC Class Codes: A61B 2562/063 in a linear array
• CPC Class Codes: A61B 2562/066 in a matrix array
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: H01F 1/0045 Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use preparation of fullerenes in general C01B32/15

Abstract

A sensor sheath for a catheter. The sensor sheath includes a substrate having at least one sensor associated therewith; and an electronics unit in communication with at the at least one sensor, wherein the substrate is configured to attach to a catheter.

Claims

1. A sensor system, comprising:

a substrate having at least one hydrogel sensor associated therewith;

a magnetometer adjacent the at least one hydrogel sensor; and

a plurality of magnetic particles associated with the at least one hydrogel sensor,

wherein the plurality of magnetic particles is arranged in a uniform alignment such that the magnetic fields of the plurality of magnetic particles are aligned in a same direction without applying an external magnetic field, and

wherein an operating distance at which the magnetic fields are detectable by the magnetometer ranges from tens of micrometers to several millimeters from the plurality of magnetic particles.

2. The sensor system of claim 1, wherein the magnetic fields of the plurality of magnetic particles are aligned in a Halbach array.

3. The sensor system of claim 1, wherein the plurality of magnetic particles comprises magnetic nanoparticles.

4. The sensor system of claim 1, further comprising an electronics unit in communication with the at least one hydrogel sensor.

5. The sensor system of claim 1, wherein the magnetic particles are embedded within the at least one hydrogel sensor.

6. The sensor system of claim 1, wherein the magnetic particles are in a layer on top of the at least one hydrogel sensor.

7. The sensor system of claim 1, wherein the at least one hydrogel sensor is sensitive to an analyte.

8. The sensor system of claim 7, wherein the analyte is protein, glucose, fructose, ionic strength/osmolality, oxidative stress, hydration, pH, CO2, O2, lactate, thrombin, fibrinogen, factor Xa, clotting factor, blood anticoagulation factor, thrombin-antithrombin complex, asymmetric dimethylarginine, soluble CD40 ligand, tumor-specific glycoprotein, C-reactive protein, creatinine, iron, hemoglobin, prostate-specific antigen, electrolyte, cholesterol components, or physiological biomarker.

9. The sensor system of claim 1, wherein the substrate comprises multiple hydrogel sensors sensitive to multiple analytes.

10. The sensor system of claim 1, wherein the sensor system is adapted for use in bioreactor composition sensing, point-of-care medical treatment, or as fully implantable, chronic/continuous sensor of physiological biomarker to monitor disease state or progress of treatment.

11. A probe, comprising the sensor system of claim 1.

12. The probe of claim 11, further comprising a disposable sleeve, wherein the at least one hydrogel sensor is located on the disposable sleeve.

13. The probe of claim 11, wherein the magnetometer is adapted to insert into the disposable sleeve.