Prediction of worsening of heart failure using blended reference
First Claim
1. A system, comprising:
- a signal input circuit configured to receive at least one physiological signal from a patient;
a signal processor circuit, including;
a memory circuit;
a reference value generator circuit including;
a filter circuit to transform one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values;
a comparator circuit to transform one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values; and
a blending circuit to generate one or more reference values of a physiologic parameter stored in the memory circuit using the respective one or more baseline statistical values and the respective one or more historical extreme values; and
a short-term value generator circuit configured to transform one or more third signal portions of the received at least one physiological signal during respective one or more third time windows into respective one or more short-term values stored in the memory circuit, the one or more third time windows shorter than the respective first and second time windows;
a cardiac condition detector circuit configured to determine a cardiac condition indicator using the one or more short-term values and the one or more reference values; and
an output unit, configured to generate a human-perceptible presentation of an indication of a progression over time of the cardiac condition indicator.
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Accused Products
Abstract
Systems and methods for detecting cardiac conditions such as events indicative of worsening of heart failure (HF) are described. A system can receive a physiological signal from a patient, transform one or more first portions of the physiological signal into respective one or more baseline statistical values, transform one or more second portions of the physiological signal into one or more historical extreme values, and generate one or more reference values of a physiologic parameter using the baseline statistical values and the historical extreme values. The system can transform one or more third signal portions of the physiological signal into respective one or more short-term values, and produce a cardiac condition indicator using a combination of relative differences between the short-term values and the corresponding reference values. The system can output the cardiac condition indicator, or deliver therapy according to the cardiac condition indicator.
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Citations
20 Claims
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1. A system, comprising:
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a signal input circuit configured to receive at least one physiological signal from a patient; a signal processor circuit, including; a memory circuit; a reference value generator circuit including; a filter circuit to transform one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values; a comparator circuit to transform one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values; and a blending circuit to generate one or more reference values of a physiologic parameter stored in the memory circuit using the respective one or more baseline statistical values and the respective one or more historical extreme values; and a short-term value generator circuit configured to transform one or more third signal portions of the received at least one physiological signal during respective one or more third time windows into respective one or more short-term values stored in the memory circuit, the one or more third time windows shorter than the respective first and second time windows; a cardiac condition detector circuit configured to determine a cardiac condition indicator using the one or more short-term values and the one or more reference values; and an output unit, configured to generate a human-perceptible presentation of an indication of a progression over time of the cardiac condition indicator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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receiving at least one physiological signal sensed from a patient using a signal input circuit; transforming one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values using a filter circuit in a reference value generator circuit of a signal processor circuit; transforming one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values using a comparator circuit in the reference value generator circuit; generating one or more reference values of a physiologic parameter stored in a memory circuit using the respective one or more baseline statistical values and the respective one or more historical extreme values using a blending circuit in the reference value generator circuit; transforming one or more third signal portions of the received at least one physiological signal during respective one or more third time windows into respective one or more short-term values stored in the memory circuit using a short-term value generator circuit of the signal processor circuit, the one or more third time windows shorter than the respective first and second time windows; determining a cardiac condition indicator using the one or more short-term values and the one or more reference values using a cardiac condition detector circuit; and generating a human-perceptible presentation of an indication of a progression over time of the cardiac condition indicator using an output unit. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification