Indolealkylamino-withasteroid conjugates and method of use
First Claim
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1. A method of treating Alzheimer'"'"'s disease in an individual, comprising administering to the individual in need of such treatment a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
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Abstract
A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer'"'"'s disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.
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4 Claims
- 1. A method of treating Alzheimer'"'"'s disease in an individual, comprising administering to the individual in need of such treatment a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- 3. A method of treating an anxiety disorder in an individual, comprising administering to the individual in need of such treatment a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
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