Polymyxin derived cell penetrating scaffolds
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Abstract
Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.
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Citations
17 Claims
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1. A compound of formula (Ia)
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2. A method of delivering cargo into mammalian cells, comprising:
a) coupling the cargo with a compound of Formula (Ia) - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of enhancing the intracellular uptake of liposomes, comprising:
a) incorporating into a liposome or liposomal assembly a compound of Formula (Ia) - View Dependent Claims (14, 15, 16, 17)
Specification