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Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins

  • US 10,449,233 B2
  • Filed: 06/29/2018
  • Issued: 10/22/2019
  • Est. Priority Date: 10/01/2015
  • Status: Active Grant
First Claim
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1. A heterologous chimeric protein comprising:

  • (a) a first domain comprising a portion of PD-1 that is at least 95% identical to SEQ ID NO;

    32 and is capable of binding a PD-1 ligand,(b) a second domain comprising a portion of OX-40 ligand (OX40L) that is at least 95% identical to SEQ ID NO;

    56 and is capable of binding an OX-40L receptor, and(c) a linker linking the first domain and the second domain and comprising a hinge-CH2-CH3 Fc domain.

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