Nutritional composition for improving the mammalian immune system

• US 10,449,248 B2
• Filed: 09/15/2014
• Issued: 10/22/2019
• Est. Priority Date: 06/23/2008
• Status: Active Grant

• Current Assignee: nv nutricia
• Original Assignee: nv nutricia
• Inventors: Faber, Joyce, Van Helvoort, Adrianus Lambertus Bertholdus, Van Norren, Klaske, Vos, Arjan Paul, Hageman, Robert Johan Joseph, Van Limpt, Cornelus Johannes Petrus
• Primary Examiner(s): Li, Ruixiang
• Application Number:
  US14/486,184
• Publication Number:
  US 20150004130A1
• Time in Patent Office: 1,863 Days
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/0628 Leucine
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/187 Eicosapentaenoic acid
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A23V 2250/54252 Whey protein
• CPC Class Codes: A61K 2039/55583 Polysaccharides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/02 Peptides of undefined number of amino acids; Derivatives thereof
• CPC Class Codes: A61K 39/39 : characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/12 : Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/42 : Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 37/02 : Immunomodulators
• CPC Class Codes: A61P 37/04 : Immunostimulants

Abstract

The invention relates to a nutritional composition comprising

• (a) at least 18 en % of proteinaceous matter;
• (b) at least 12 wt % of leucine, based on total proteinaceous matter;
• (c) a lipid fraction comprising at least a ω-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid;
• (d) an immune modulator;
• for improving the immune function in a mammal, preferably a human.

Claims

1. A method for treating neutropenia in a mammal, comprising administering a nutritional composition to the mammal in need thereof, said nutritional composition comprising:

(a) 18-50 en % of proteinaceous matter;

(b) at least 12 wt % of leucine, based on total proteinaceous matter;

(c) 10-50 en % of lipids, said lipids comprise at least 15 wt % based on total lipid content of a ω

-3 polyunsaturated fatty acid selected from eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid;

(d) 20-50 en % of digestible carbohydrates;

(e) 1-15 wt % of indigestible galactooligosaccharide and fructooligosaccharide, based on total dry matter, the molar ratio of said galactooligosaccharide and fructooligosaccharide ranges from 1;

1 to 20;

1, said nutritional composition has an energetic value of between 0.3 kcal/ml and 3.0 kcal/ml if it is provided as a liquid nutritional composition or an energetic value of between 3.2 kcal/g and 8.0 kcal/g if it is provided as a semi-liquid, gel or solid nutritional composition.

2. The method according to claim 1, wherein the mammal has a reduced immune function which manifests itself as a symptom selected from the group consisting of infections, inflammations, vascular complications, bad wound healing, mucositis and stomatitis.

3. The method according to claim 1, wherein the nutritional composition is administered to a mammal suffering from cancer.

4. The method according to claim 1, wherein the mammal has a trauma selected from the group consisting of surgery, drug treatment, chemotherapy and radiotherapy.

5. The method according to claim 1, wherein the nutritional composition is administered to a mammal receiving an anti-cancer immunotherapy or planning to start anti-cancer immunotherapy within a period of two months, and wherein the nutritional composition enhances the effectiveness of an immunotherapy.

6. The method according to claim 1, wherein the nutritional composition is a liquid nutritional composition comprising at least 7 g/100 ml of proteinaceous matter.

7. The method according to claim 1, wherein the proteinaceous matter originates from at least one protein source selected from the group of whey protein, casein, caseinate, soy protein and wheat protein.

8. The method according to claim 1, wherein the proteinaceous matter comprises at least 15 wt. % whey protein.

9. The method according to claim 1, wherein the nutritional composition comprises leucine in the form of a free acid, a salt, a dipeptide or a conjugate with a conjugating compound other than an amino acid, a protein, or a peptide, which conjugate is capable of being split into the free amino acid or salt thereof.

10. The method according to claim 1, comprising between 12 wt. % and 23 wt. % of leucine, based on total proteinaceous matter.

11. The method according to claim 1, comprising between 4 wt. % and 20 wt. % of glutamine, based on total proteinaceous matter.

12. The method according to claim 1, wherein the nutritional composition comprises at least 0.7 wt. % of one or more of the group of cystine, cysteine and cysteine equivalents.

13. The method according to claim 1, wherein the lipid fraction comprises less than 30 wt. % of a saturated fatty acid.

14. The method according to claim 1, wherein the lipid fraction further comprises at least one ω

-6 polyunsaturated fatty acid, and wherein the molar ratio of ω

-3 polyunsaturated fatty acids to ω

-6 polyunsaturated fatty acids is less than 1.0.

15. The method according to claim 1, wherein the nutritional composition further comprises at least one component selected from the group consisting of sodium, potassium, chloride, fluoride, iodide, calcium, phosphorous, magnesium, vitamin A, vitamin D3, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, folic acid, vitamin B12, biotin, vitamin C, lipoic acid, zinc, iron, copper, manganese, molybdenum, selenium and chromium.

16. The method according to claim 1, wherein the mammal is a human.

17. The method according to claim 1, wherein the nutritional composition is administered orally.

18. The method according to claim 1, wherein the nutritional composition is administered enterally.

19. The method according to claim 1, wherein the nutritional composition is administered under supervision of a medical specialist.

20. The method according to claim 16, wherein the nutritional composition is self-administered.

21. The method according to claim 7, wherein the proteinaceous matter originates from at least one protein source selected from the group consisting of whey protein and casein.

22. The method according to claim 1, wherein the nutritional composition comprises a digestible carbohydrate and the nutritional composition has a glycemic index of less than 55.

23. The method according to claim 1, wherein the neutropenia is chemotherapy-induced neutropenia.

24. The method according to claim 1, wherein the indigestible carbohydrate comprises a short chain galactooligosaccharide and a short chain fructooligosaccharide.