Hydrogel composition and method for using the same

• US 10,449,272 B2
• Filed: 10/14/2016
• Issued: 10/22/2019
• Est. Priority Date: 10/16/2015
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Wang, Yu-Chi, Shen, Hsin-Hsin, Chen, Chin-Fu, Hsieh, Meng-Yow, Chen, Sen-Lu, Liou, Yu-Bing, Lin, Tsai-Yu, Li, Pei-Shan, Yu, Wei-Lin
• Primary Examiner(s): Pipic, Alma
• Application Number:
  US15/294,047
• Publication Number:
  US 20170106125A1
• Time in Patent Office: 1,103 Days
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

Claims

1. A hydrogel composition, comprising:

a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows;

A-B-BOX-B-A, 

 

Formula (I);

B-A-B-(BOX-BAB)n-BOX-B-A-B, 

 

Formula (II),

wherein, the polymer block A is polyethylene glycol (PEG) or methoxy-poly(ethylene glycol) (mPEG), the polymer block B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2′

-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and

hyaluronic acid,

wherein a weight ratio of the hyaluronic acid to the hydrogel is 0.05-0.1;

3, and

wherein the hydrogel composition has an anti-adhesion effect and is temperature sensitive.

2. The hydrogel composition as claimed in claim 1, wherein the polymer block B comprises poly(lactide-co-glycolide) (PLGA), poly(propionic-co-lactic) (PPLA), poly(valeric-co-lactic) (PVLA) or poly(caproic-co-lactic) (PCLA).

3. The hydrogel composition as claimed in claim 1, wherein the hydrogel composition is powder.

4. The hydrogel composition as claimed in claim 3, wherein a particle size of the powder is between 0.1 μ

m and 1 mm.

5. A method of making a gel, comprising:

dissolving the hydrogel composition as claimed in claim 1 in water at a first temperature to form a liquid; and

applying the liquid to a substrate, wherein the substrate has a second temperature, and the liquid forms into a gel at the second temperature.

6. The method of making a gel as claimed in claim 5, wherein the first temperature is between 4°

C. and 30°

C.

7. The method of making a gel as claimed in claim 5, wherein a viscosity of the liquid is less than 100 Pa-s.

8. The method of making a gel as claimed in claim 5, wherein the second temperature is between 30°

C. and 55°

C.

9. The method of making a gel as claimed in claim 5, wherein a viscosity range of the gel is between 200 Pa-s and 250 Pa-s.

10. A hydrogel composition, comprising:

a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows;

A-B-BOX-B-A, 

 

Formula (I);

B-A-B-(BOX-BAB)n-BOX-B-A-B, 

 

Formula (II),

wherein, the polymer block A is polyethylene glycol (PEG) or methoxy-polyethylene glycol) (mPEG), the polymer block B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′

-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and

an anti-adhesion additive,

wherein the anti-adhesion additive comprises glucose, poly(vinyl alcohol) (PVA) or poly(ethylene glycol)diacrylate (PEGDA) and

wherein the anti-adhesion additive is glucose and a weight ratio of the anti-adhesion additive to the hydrogel is 0.02-0.1;

3, or wherein the anti-adhesion additive is poly(vinyl alcohol) (PVA) and a weight ratio of the anti-adhesion additive to the hydrogel is 0.12-6;

3, or wherein the anti-adhesion additive is poly(ethylene glycol)diacrylate (PEGDA) and a weight ratio of the anti-adhesion additive to the hydrogel is 0.01-6;

3, and

wherein the hydrogel composition has an anti-adhesion effect and is temperature-sensitive.