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Hydrogel composition and method for using the same

  • US 10,449,272 B2
  • Filed: 10/14/2016
  • Issued: 10/22/2019
  • Est. Priority Date: 10/16/2015
  • Status: Active Grant
First Claim
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1. A hydrogel composition, comprising:

  • a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows;


    A-B-BOX-B-A, 



    Formula (I);


    B-A-B-(BOX-BAB)n-BOX-B-A-B, 



    Formula (II),wherein, the polymer block A is polyethylene glycol (PEG) or methoxy-poly(ethylene glycol) (mPEG), the polymer block B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2′

    -Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and

    hyaluronic acid,wherein a weight ratio of the hyaluronic acid to the hydrogel is 0.05-0.1;

    3, andwherein the hydrogel composition has an anti-adhesion effect and is temperature sensitive.

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