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Fluid injection devices and related methods

  • US 10,449,298 B2
  • Filed: 03/26/2015
  • Issued: 10/22/2019
  • Est. Priority Date: 03/26/2015
  • Status: Active Grant
First Claim
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1. A method of operating an injection pen to deliver insulin to a patient, the method comprising:

  • receiving user input indicative of a desire to administer a bolus using the injection pen;

    receiving, at the injection pen via a wireless network, one or more interstitial fluid glucose measurement values from an interstitial sensing arrangement including one or more interstitial sensing elements;

    obtaining, at the injection pen, a blood glucose measurement value measured by a blood glucose meter;

    adjusting, at the injection pen, the blood glucose measurement value most recently measured by the blood glucose meter based at least in part on the one or more interstitial fluid glucose measurement values from the interstitial sensing arrangement to obtain an adjusted blood glucose measurement value corresponding to a time for the bolus to be delivered in response to receiving the user input indicative of the desire to administer the bolus;

    recursively determining, at the injection pen, an active amount of the insulin in a body of the patient at the time for the bolus to be delivered based at least in part on historical bolus data associated with previous boluses delivered to the patient using the injection pen and an insulin action speed associated with the patient, wherein the insulin action speed represents an amount of time required to clear a unit of insulin from the body of the patient;

    after receiving the user input, determining, by the injection pen, a bolus delivery amount of the insulin based at least in part on the active amount of the insulin and a difference between the adjusted blood glucose measurement value and a target glucose value;

    configuring, by the injection pen, an actuation arrangement of the injection pen to automatically deliver the bolus delivery amount in response to actuation of a user interface element of the injection pen.

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