Platelet-derived growth factor B mutant, preparation method therefor and use thereof
First Claim
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1. A human, mature platelet-derived growth factor B (PDGF-B) mutant wherein the threonines at amino acid positions 101 and 109 are substituted with alanine, and wherein the PDGF-B mutant has PDGF-B activity.
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Abstract
Provided are a platelet-derived growth factor B derivative, the encoding nucleic acid molecule thereof, and a vector and host cell having the nucleic acid molecule. Also provided are a preparation method for the mutant, and the use of the mutant in preparing medications for promoting cell division, cell proliferation, wound healing, skin regeneration, bone and tooth defect regeneration, and joint repair.
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11 Claims
- 1. A human, mature platelet-derived growth factor B (PDGF-B) mutant wherein the threonines at amino acid positions 101 and 109 are substituted with alanine, and wherein the PDGF-B mutant has PDGF-B activity.
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11. A human, mature platelet-derived growth factor B (PDGF-B) mutant, comprising the sequence set forth in SEQ ID NO:
- 3 or SEQ ID NO;
5.
- 3 or SEQ ID NO;
Specification