Polyomavirus neutralizing antibodies
First Claim
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1. A pharmaceutical composition comprising an antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
6, (b) a HCDR2 of SEQ ID NO;
7, (c) a HCDR3 of SEQ ID NO;
8 and a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
16, (e) a LCDR2 of SEQ ID NO;
17, and (f) a LCDR3 of SEQ ID NO;
18 and a pharmaceutically acceptable carrier.
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Abstract
The present disclosure is directed to anti-VP1 antibodies, antibody fragments, and their uses for the reducing the likelihood or treatment of polyoma virus infection.
5 Citations
21 Claims
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1. A pharmaceutical composition comprising an antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
6, (b) a HCDR2 of SEQ ID NO;
7, (c) a HCDR3 of SEQ ID NO;
8 and a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
16, (e) a LCDR2 of SEQ ID NO;
17, and (f) a LCDR3 of SEQ ID NO;
18 and a pharmaceutically acceptable carrier. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 18)
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
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6. A pharmaceutical composition comprising an antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof comprises:
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
6, (b) a HCDR2 of SEQ ID NO;
7, (c) a HCDR3 of SEQ ID NO;
8 and a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
16, (e) a LCDR2 of SEQ ID NO;
17, and (1) a LCDR3 of SEQ ID NO;
18 wherein the composition is prepared as a lyophilisate. - View Dependent Claims (15, 16, 17, 19, 20, 21)
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
Specification