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Anti-complement C1s antibodies

  • US 10,450,382 B2
  • Filed: 12/20/2016
  • Issued: 10/22/2019
  • Est. Priority Date: 11/02/2012
  • Status: Active Grant
First Claim
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1. A humanized antibody that binds complement C1s protein and comprises:

  • a light chain variable region that comprises a CDR-L1 amino acid sequence set forth in SEQ ID NO;

    1, a CDR-L2 amino acid sequence set forth in SEQ ID NO;

    2, and a CDR-L3 amino acid sequence set forth in SEQ ID NO;

    3;

    a heavy chain variable region that comprises a CDR-H1 amino acid sequence set forth in SEQ ID NO;

    4, a CDR-H2 amino acid sequence set forth in SEQ ID NO;

    5, and a CDR-H3 amino acid sequence set forth in SEQ ID NO;

    6; and

    an IgG4 constant region comprising an S241P substitution (by Kabat numbering) and an L235E substitution (by EU numbering).

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