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Compositions of alpha-1 antitrypsin fusion molecules

  • US 10,450,384 B2
  • Filed: 03/14/2018
  • Issued: 10/22/2019
  • Est. Priority Date: 06/24/2011
  • Status: Active Grant
First Claim
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1. An isolated fusion polypeptide comprising at least one human alpha-1 antitrypsin (AAT) polypeptide comprising an amino acid sequence selected from the group consisting of an AAT polypeptide sequence represented by SEQ ID NO:

  • 52, SEQ ID NO;

    53, or SEQ ID NO;

    54 wherein the AAT polypeptide is operably linked to an immunoglobulin Fc polypeptide through a linker and wherein the Fc polypeptide comprises an Fc polypeptide of IgG1, IgG2, IgG3, IgG4 or IgD.

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