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Delivery methods and compositions for nuclease-mediated genome engineering

  • US 10,450,585 B2
  • Filed: 07/13/2016
  • Issued: 10/22/2019
  • Est. Priority Date: 07/13/2015
  • Status: Active Grant
First Claim
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1. A method of introducing a donor nucleic acid molecule into an isolated cell, the method comprising:

  • administering to the cell at least one adeno-associated virus (AAV) vector comprising a donor nucleic acid molecule in the presence of at least one inhibitor of Platelet-derived growth factor receptor under conditions sufficient to increase efficiency of viral delivery to the cell, wherein the AAV vector has an AAV6 capsid.

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