Optical fibre for use in a system for detection of one or more compounds in a fluid

• US 10,451,549 B2
• Filed: 05/16/2016
• Issued: 10/22/2019
• Est. Priority Date: 05/18/2015
• Status: Active Grant

• Current Assignee: International Iberian Nanotechnology Laboratory
• Original Assignee: International Iberian Nanotechnology Laboratory
• Inventors: Viegas, Diana, Queiros, Raquel, Nieder, Jana, Fernandez, Maria Teresa, Espina, Begona, Freitas, Paolo, Montelius, Lars
• Primary Examiner(s): Peace, Rhonda S
• Application Number:
  US15/574,732
• Publication Number:
  US 20180143133A1
• Time in Patent Office: Days
• CPC Class Codes: G01N 2021/7716 in cladding
• CPC Class Codes: G01N 21/553 and using surface plasmons fluorescence excitation G01N21/648; enhanced Raman G01N21/658
• CPC Class Codes: G01N 21/554 detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 2201/088 Using a sensor fibre
• CPC Class Codes: G01N 2201/0886 and using OTDR

Abstract

The present invention relates to an optical fiber for use in a system for detection of one or more compounds in a fluid. The optical fiber (100, 101, 202) comprising at least two binding portions (102, 104, 118, 210, 211, 212) separated from each other along the longitudinal direction (106) of the optical fiber (100, 101, 202), wherein each of the at least two binding portions (102, 104, 118, 210, 211, 212) comprises a plasmonic structure (120) and/or a SERS structure (121), and a binding material (126) for binding of one or more compounds, wherein at least two binding portions (102, 104, 118, 210, 211, 212) are arranged for binding the same compound or compounds, wherein the optical fiber (100, 101, 202) is arranged for receiving light and transmitting light to each of the at least two binding portions, wherein each of the at least two binding portions (102, 104, 118, 210, 211, 212) is arranged such that light transmitted through that binding portion (102, 104, 118, 210, 211, 212) without bound compound is different compared to light transmitted through that binding portion (102, 104, 118, 210, 211, 212) with bound compound, or light reflected back from that binding portion (102, 104, 118, 210, 211, 212) without bound compound is different compared to light reflected back from that binding portion (102, 104, 118, 210, 211, 212) with bound compound. The present invention further relates to a system (200) for detection of one or more compounds in a fluid (103) and an optical fiber (100, 101, 202) for use in such a system (200) and a method (400) using the system (200).

Claims

1. A system for detection of one or more compounds in a fluid, the system comprising:

an optical fibre comprising;

a light entrance, and

at least two binding portions separated from each other along a longitudinal direction of the optical fibre, wherein

each of the at least two binding portions comprises;

a plasmonic structure and/or a SERS structure, and

a binding material for binding one or more compounds,

at least two of the binding portions are arranged for binding a same compound or compounds,

the binding material is arranged on the plasmonic structure and/or the SERS structure,

the optical fibre is arranged for receiving light and transmitting light to each of the at least two binding portions, and

each of the at least two binding portions is arranged such that

light transmitted through that binding portion without bound compound is different compared to light transmitted through that binding portion with bound compound, or

light reflected back from that binding portion without bound compound is different compared to light reflected back from that binding portion with bound compound;

a light source arranged for transmitting light through the light entrance into the optical fibre and thereby to each of the at least two binding portions, the light source being a pulsed light source; and

an optical time-domain reflectometer (OTDR) that includes a time resolving detector, wherein the time resolving detector is configured to detect light reflected from each binding portion of the at least two binding portions separately.

2. The system according to claim 1, wherein the light source is a broad band light source.

3. The system according to claim 1, wherein the OTDR further comprises a wavelength dispersing element.

4. The system according to claim 1, further comprising a transceiver for transceiving data to, from, or within the system.

5. The system according to claim 1, wherein

the optical fibre comprises at least three binding portions, and

the at least two binding portions are arranged for binding different compounds.

6. The system according to claim 1, wherein the binding material comprises functionalising groups or molecular imprints.

7. A method for analyzing a fluid at a plurality of locations using a system that includes:

an optical fibre including at least two binding portions separated from each other along a longitudinal direction of the optical fibre, wherein

each of the at least two binding portions comprises a plasmonic structure and/or a SERS structure, and a binding material for binding one or more compounds,

at least two of the binding portions are arranged for binding a same compound or compounds,

the binding material is arranged on the plasmonic structure and/or the SERS structure,

the optical fibre is arranged for receiving light and transmitting light to each of the at least two binding portions,

each of the at least two binding portions is arranged such that light transmitted through that binding portion without bound compound is different compared to light transmitted through that binding portion with bound compound, or light reflected back from that binding portion without bound compound is different compared to light reflected back from that binding portion with bound compound, and

the at least two binding portions are arranged for binding the same compound or compounds,

a light source arranged for transmitting light through a light entrance of the optical fibre, the light source being a pulsed light source, and

an optical time-domain reflectometer (OTDR) that includes a time resolving detector,

the method comprising;

transmitting, with the light source, light through the optical fibre and to each of the at least two binding portions;

detecting, with the OTDR, light reflected from each binding portion of the at least two binding portions separately; and

determining, based on the detecting, if one or more compounds are bound to the least two binding portions respectively.

8. The method according to claim 7, further comprising:

comparing first data with second data, the first resulting from the determining pertaining to one of the at least two binding portions and the second data resulting from the determining pertaining to another one of the at least two binding portions.