Detection system and method with nanostructure flow cell
First Claim
1. A system for optically determining concentration of a constituent of a sample fluid in real time, the system comprising:
- a flow cell configured to convey the sample fluid therethrough from a proximal end to a distal end;
a light source disposed in optical communication with the proximal end of the flow cell, the light source configured to emit incident light of an incident light spectrum into the flow cell;
media disposed within the flow cell;
nanostructures supported by the media, the nanostructures being substantially transparent in at least a portion of the incident light spectrum, the nanostructures configured to adsorb or absorb the constituent to attain a nanostructures concentration that is a predetermined multiple of a sample concentration of the constituent in the sample fluid passing through the flow cell;
at least one sensor disposed at the distal end of the flow cell, the sensor configured to detect transmitted light exiting from the media, and to generate one or more outputs corresponding to a transmitted light spectrum of the transmitted light;
a processor communicably coupled to the sensor, the processor configured to capture the outputs from the sensor, and to compare the incident light spectrum to the transmitted light spectrum to generate an absorbance spectrum;
the processor further configured to use the absorbance spectrum to calculate the nanostructures concentration, and to use the nanostructures concentration and the predetermined multiple to calculate the sample concentration.
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Abstract
A system and method for determining concentration of a constituent of a sample fluid includes a flow cell with a light source emitting incident light to a proximal end thereof. Media disposed within the flow cell supports nanostructures that are substantially transparent in at least a portion of the incident light spectrum. The nanostructures adsorb or absorb the constituent to attain a concentration that is a multiple of the concentration of the constituent in the sample fluid. A sensor detects transmitted light exiting from the media, and generates outputs corresponding to a spectrum of the transmitted light. A processor captures the sensor outputs and compares the incident light spectrum to the transmitted light spectrum to generate an absorbance spectrum. The absorbance spectrum is used to calculate the concentration in the nanostructures, which is then used with the predetermined multiple to calculate the sample concentration.
66 Citations
20 Claims
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1. A system for optically determining concentration of a constituent of a sample fluid in real time, the system comprising:
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a flow cell configured to convey the sample fluid therethrough from a proximal end to a distal end; a light source disposed in optical communication with the proximal end of the flow cell, the light source configured to emit incident light of an incident light spectrum into the flow cell; media disposed within the flow cell; nanostructures supported by the media, the nanostructures being substantially transparent in at least a portion of the incident light spectrum, the nanostructures configured to adsorb or absorb the constituent to attain a nanostructures concentration that is a predetermined multiple of a sample concentration of the constituent in the sample fluid passing through the flow cell; at least one sensor disposed at the distal end of the flow cell, the sensor configured to detect transmitted light exiting from the media, and to generate one or more outputs corresponding to a transmitted light spectrum of the transmitted light; a processor communicably coupled to the sensor, the processor configured to capture the outputs from the sensor, and to compare the incident light spectrum to the transmitted light spectrum to generate an absorbance spectrum; the processor further configured to use the absorbance spectrum to calculate the nanostructures concentration, and to use the nanostructures concentration and the predetermined multiple to calculate the sample concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for optically determining concentration of a constituent of a sample fluid in real time, the method comprising:
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(a) conveying the sample fluid from a proximal end to a distal end of a flow cell; (b) emitting, with a light source disposed in optical communication with the proximal end of the flow cell, incident light of an incident light spectrum into the flow cell, the flow cell including media therein, and nanostructures supported by the media, the nanostructures being substantially transparent in at least a portion of the incident light spectrum, the nanostructures configured to adsorb or absorb the constituent to attain a nanostructures concentration that is a predetermined multiple of a sample concentration of the constituent in the sample fluid passing through the flow cell; (c) detecting, with at least one sensor disposed at the distal end of the flow cell, transmitted light exiting from the media; (d) generating one or more outputs corresponding to a transmitted light spectrum of the transmitted light; (e) capturing, with a processor communicably coupled to the sensor, the outputs from the sensor, and (f) comparing, with the processor, the incident light spectrum to the transmitted light spectrum to generate an absorbance spectrum; (g) calculating, with the processor, the nanostructures concentration using the absorbance spectrum, and (h) calculating, with the processor, the sample concentration using the nanostructures concentration and the predetermined multiple. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification