RF ion guide with axial fields

• US 10,453,666 B2
• Filed: 07/23/2018
• Issued: 10/22/2019
• Est. Priority Date: 06/13/2014
• Status: Active Grant

• Current Assignee: Perkin Elmer Life Sciences
• Original Assignee: Perkinelmer Health Sciences Incorporated (Perkinelmer Incorporated)
• Inventors: Welkie, David G.
• Primary Examiner(s): Smith, David E
• Application Number:
  US16/042,531
• Publication Number:
  US 20190043705A1
• Time in Patent Office: 456 Days
• CPC Class Codes: H01J 49/0031 Step by step routines describing the use of the apparatus H01J49/0081 takes precedence
• CPC Class Codes: H01J 49/0045 characterised by the fragmentation or other specific reaction
• CPC Class Codes: H01J 49/005 by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles
• CPC Class Codes: H01J 49/40 Time-of-flight spectrometers H01J49/36 takes precedence

Abstract

RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions.

Claims

1. An apparatus, comprising:

an ion source;

a mass analyzer;

a RF ion guide positioned in an ion path between the ion source and the mass analyzer, the RF ion guide having an ion guide axis extending between an input end of the RF ion guide and an exit end of the RF ion guide, the RF ion guide comprising;

a first rectilinear electrode extending along the ion guide axis, the first electrode configured to be connected to a voltage source, and

a second rectilinear electrode extending along the ion guide axis, the second electrode configured to be connected to a RF source, a portion of the second electrode being positioned between the first electrode and the ion guide axis, the second electrode defining a longitudinal elongated slot extending through a plane of the second electrode, wherein during use of the apparatus, the RF ion guide produces RF electric fields within a central portion of the RF ion guide throughout a region between the second electrode and the ion guide axis to radially confine ions,

wherein the first electrode comprises a first face and a second face adjacent to the first face, the first face and the second face extending parallel to the ion guide axis, the first face having a greater surface area than the second face, the first face disposed beyond the plane of the second electrode and facing the ion guide axis,

wherein the first and second electrodes are configured so that during operation of the apparatus, a DC electric field is generated between the first and second electrodes to provide a DC electric field at the ion guide axis that has a non-zero axial component throughout at least a portion of the length of the RF ion guide.

2. The apparatus of claim 1, wherein the slot varies in width along a length of the slot.

3. The apparatus of claim 2, wherein the slot increases in width from a first longitudinal end of the slot to a second longitudinal end of the slot.

4. The apparatus of claim 3, wherein the first longitudinal end of the slot is proximal to the input end of the RF ion guide, and wherein the second longitudinal end of the slot is proximal to the exit end of the RF ion guide.

5. The apparatus of claim 1, wherein the first electrode is parallel to the second electrode.

6. The apparatus of claim 1, further comprising one or more additional first electrodes and one or more additional second electrodes,

wherein each additional first electrode extends along the ion guide axis and is configured to be connected to the voltage source;

and

wherein each additional second electrode extends along the ion guide axis, is configured to be connected to the RF source, and defines a respective additional longitudinal elongated slot, and wherein during use of the apparatus, the additional second electrodes produce RF electric fields within the central portion of the RF ion guide throughout the region between the second electrode and the ion guide axis to radially confine the ions.

7. The apparatus of claim 6, wherein, for each additional second electrode, the respective slot varies in width along a length of the slot.

8. The apparatus of claim 6, wherein each additional first electrode is parallel to a corresponding one of the additional second electrodes.

9. A method, comprising:

ionizing a sample to generate ions;

providing background gas along at least a portion of a RF ion guide;

introducing at least a portion of the ions through an input end of the RF ion guide to collide with background gas in the RF ion guide;

providing a DC electric field along an ion guide axis of the RF ion guide that has a non-zero axial component to cause ions that have undergone collisions to move through the RF ion guide toward a ion guide exit end;

wherein providing the axial electric field comprises applying a DC voltage to a plurality of first electrodes of the RF ion guide that surrounds a plurality of second electrodes of the RF ion guide, each extending along the guide axis, such that an electric field produced by the plurality of first electrodes penetrates respective central portions of the plurality of second electrodes before impinging on the ion guide axis to generate a DC electric field between the plurality of first electrodes and the plurality of second electrodes, the central portions of the plurality of second electrodes defining respective longitudinal elongated slots, and wherein the RF ion guide produces RF electric fields within a central portion of the RF ion guide throughout a region between the plurality of second electrodes and the ion guide axis to radially confine at least a portion of the ions that have undergone collisions;

providing a first trapping region proximal to the ion guide exit end, wherein at least a portion of the radially confined ions are trapped following their passage through the RF ion guide;

releasing trapped ions from the first trapping region; and

mass analyzing the released ions.

10. The method of claim 9, wherein each of the slots varies in width along a length of the slot.

11. The method of claim 10, wherein each of the slots increases in width from a first longitudinal end of the slot to a second longitudinal end of the slot.

12. The method of claim 11, wherein, for each of the slots, the first longitudinal end of the slot is proximal to the input end of the RF ion guide, and wherein the second longitudinal end of the slot is proximal to the exit end of the RF ion guide.

13. The method of claim 9, wherein each electrode of the plurality of first electrodes is parallel to a corresponding electrode of the plurality of second electrodes.

14. The method of claim 9, further comprising:

selecting a range of mass-to-charge values from said ions with a mass analyzer before introducing at least a portion of the mass-to-charge selected ions through an input end of a second RF ion guide to collide with background gas in the second RF ion guide.

15. The method of claim 9, wherein providing background gas along at least a portion of the RF ion guide comprises providing a background gas pressure high enough that collisions between at least the portion of the ions and background gas results in collision cooling of at least the portion of ions.