Confectionary products with calcium phosphate

• US 10,455,847 B2
• Filed: 11/27/2014
• Issued: 10/29/2019
• Est. Priority Date: 11/29/2013
• Status: Active Grant

• Current Assignee: Perfetti Van Melle S.P.A.
• Original Assignee: Perfetti Van Melle S.P.A.
• Inventors: Colle, Roberto, Sarrica, Andrea
• Primary Examiner(s): Roberts, Lezah
• Application Number:
  US15/039,422
• Publication Number:
  US 20160374363A1
• Time in Patent Office: 1,797 Days
• CPC Class Codes: A23G 3/362 containing inorganic compounds
• CPC Class Codes: A23G 3/54 Composite products, e.g. layered, coated, filled
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/062 Products for covering, coating, finishing, decorating
• CPC Class Codes: A23G 4/064 containing inorganic compounds
• CPC Class Codes: A23G 4/20 Composite products, e.g. centre-filled , multi-layer, laminated
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2800/30 Characterized by the absence of a particular group of ingredients
• CPC Class Codes: A61K 8/0204 Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention relates to confectionary products containing a synergic combination of dibasic calcium phosphate and tribasic calcium phosphate. Confectionary products are useful in the treatment of dentinal sensitivity.

Claims

1. A method of treating dentinal sensitivity in a subject in need thereof, said method comprising:

administering to said subject a confectionary product free from acids and comprising calcium phosphate, wherein said calcium phosphate consists of from 0.7% to 18% by weight of dibasic calcium phosphate and from 0.07% to 3.6% by weight of tribasic calcium phosphate.

2. The method according to claim 1 wherein dibasic calcium phosphate is selected from anhydrous dibasic calcium phosphate, dibasic calcium phosphate dihydrate and mixtures thereof.

3. The method according to claim 1 wherein said dibasic calcium phosphate has at least 30% of the particles with a size larger than 50 μ

m.

4. The method according to claim 1 wherein tribasic calcium phosphate is selected from calcium orthophosphate, calcium hydroxyapatite and mixtures thereof.

5. The method according to claim 1 wherein said tribasic calcium phosphate has 100% of the particles with a size ranging from 0.10 μ

m to 60 μ

m.

6. The method according to claim 1 wherein said tribasic calcium phosphate has at least 90% of the particles with a size of less than 0.3 μ

m.

7. The method according to claim 6 wherein said tribasic calcium phosphate has at least 90% of the particles with a size of less than 0.010 μ

m.

8. The method according to claim 1, wherein in a single piece, dibasic calcium phosphate is present in amounts ranging from 10 mg to 250 mg and tribasic calcium phosphate is present in amounts ranging from 1 mg to 50 mg.

9. The method according to claim 1 containing fluoride in amounts ranging from 0.001% to 0.1%.

10. The method according to claim 1, said confectionary product consists of a chewing gum dragee, comprising:

i) a first region comprising a gum base as a core and said dibasic calcium phosphate; and

ii) a second region that is a water-soluble coating layer, which comprises said tribasic calcium phosphate and no gum base, wherein said tribasic calcium phosphate comprises more than 60% of the dry weight of the coating layer;

wherein said second region at least partially coats said first region i).

11. The method according to claim 10, wherein the coating layer of the chewing gum dragee comprises a polyol selected from the group consisting of xylitol, sorbitol, maltitol, mannitol, erythritol, glucopyranosyl-mannitol, glucopyranosyl-sorbitol and mixtures thereof;

wherein the polyol comprises more than 60% of the dry weight of the coating layer.

12. The method according to claim 1, said confectionary product is a chewing gum comprising:

i) a first region comprising a gum base and said dibasic calcium phosphate; and

ii) a second region comprising said tribasic calcium phosphate and no gum base;

wherein the second region is water soluble;

wherein the first region i) and the second region ii) are layered, mutually alternating regions.

15. The method according to claim 1 comprising administration of 2 to 10 pieces daily of said confectionary product.

16. The method according to claim 1, wherein said confectionary product is selected from the group consisting of candies, chewing gum and tablets.

13. A method of treating and preventing dentine and enamel demineralization in a subject in need thereof, said method comprising:

administering to said subject a confectionary product free from acids and comprising calcium phosphate, wherein said calcium phosphate consists of from 0.7% to 18% by weight of dibasic calcium phosphate and from 0.07% to 3.6% by weight of tribasic calcium phosphate.

14. A method of treating and preventing dental caries in a subject in need thereof, said method comprising:

administering to said subject a confectionary product free from acids and comprising calcium phosphate, wherein said calcium phosphate consists of from 0.7% to 18% by weight of dibasic calcium phosphate and from 0.07% to 3.6% by weight of tribasic calcium phosphate.