Nutritional supplement composition suitable for improving lean tissue mass status in an adult human

• US 10,455,853 B2
• Filed: 05/26/2015
• Issued: 10/29/2019
• Est. Priority Date: 05/30/2014
• Status: Active Grant

• Current Assignee: University of Limerick
• Original Assignee: University of Limerick
• Inventors: Jakeman, Phil
• Primary Examiner(s): Worsham, Jessica
• Application Number:
  US15/315,295
• Publication Number:
  US 20180184700A1
• Time in Patent Office: 1,617 Days
• Field of Search: None
• CPC Class Codes: A23L 33/00 Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
• CPC Class Codes: A23L 33/155 Vitamins A or D
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 9/009 Sachets, pouches characterised by the material or function of the envelope with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system

Abstract

“A nutritional supplement composition suitable for improving lean tissue mass status in a mammal” A nutritional supplement suitable for increasing lean tissue mass in a mammal comprises protein, vitamin D, and calcium. The protein comprises a casein-based milk protein composition, a hydrolyzed whey-based milk protein composition having insulinotropic bioactivity, and a hydrolyzed whey-based milk protein composition having anti-oxidant bioactivity. The supplement increases lean tissue mass in a subject.

Claims

1. A nutritional supplement suitable for increasing lean tissue mass in a mammal, the supplement comprising per 100 g dry weight at least 60 g of a protein component, 0.01 mg to 0.1 mg vitamin D, and 1 g to 5 g calcium, and in which the protein component comprises:

50 g-60 g of a casein-based milk protein composition,

5 g-15 g of a first hydrolysed whey-based milk protein composition having insulinotropic bioactivity; and

4 g-8 g of a second hydrolysed whey-based milk protein composition having antioxidant bioactivity.

2. A nutritional supplement as claimed in claim 1, in which the protein component comprises:

52 g-56 g of a casein-based milk protein composition,

11.7 g-12.5 g of the first hydrolysed whey-based milk protein composition; and

5.8 g-6.2 g of the second whey-based milk protein composition.

3. A nutritional supplement as claimed in claim 1 and comprising:

60 g-80 g of the protein component;

3 g-4 g calcium; and

0.04 mg-0.07 mg vitamin D.

4. A nutritional supplement as claimed in claim 1 and comprising:

67 g-73 g of the protein component;

2.5 g-3 g calcium; and

0.05 mg-0.06 mg vitamin D.

5. A nutritional supplement as claimed in claim 1, in which the casein-based milk protein composition is a milk protein concentrate.

6. A nutritional supplement as claimed in claim 1, in which the first hydrolysed whey-based milk protein composition having insulinotropic activity is enzymatically hydrolysed whey protein concentrate having a degree of hydrolysis of 30-35% DH.

7. A nutritional supplement as claimed in claim 1, in which the second hydrolysed whey-based milk protein composition having anti-oxidant activity is enzymatically hydrolysed whey protein isolate having a degree of hydrolysis of 42-47% DH.

8. A nutritional supplement composition as claimed in claim 1 in which the protein component has an essential amino acid content of at least 40 g/100 g protein.

9. A nutritional supplement according to claim 1, wherein the nutritional supplement is provided in the form of a single dose suitable for administration with a meal and the single dose comprises 8 g to 17 g of the protein component, 6 μ

g to 13 μ

g vitamin D, and 250 mg to 500 mg calcium.

10. A nutritional supplement as claimed in claim 1, wherein the nutritional supplement is provided in the form of a single dose suitable for administration with a meal, and the single dose comprises 8 g to 17 g of the protein component, 6 μ

g to 13 μ

g vitamin D, and 250 mg to 500 mg calcium, wherein the single dose is a powder in a sachet.

11. A nutritional supplement as claimed in claim 1, wherein the nutritional supplement is provided in the form of a single dose suitable for administration with a meal, and the single dose comprises 8 g to 17 g of the protein component, 6 μ

g to 13 μ

g vitamin D, and 250 mg to 500 mg calcium, wherein the single dose is a powder divided between two sachets, in which the sachets are provided as a single package unit with a tear line dividing the two sachets.