Systems and methods for generating non-contact ultrasound images using photoacoustic energy

• US 10,456,044 B2
• Filed: 11/11/2014
• Issued: 10/29/2019
• Est. Priority Date: 11/22/2013
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Haupt, Robert W., Wynn, Charles M.
• Primary Examiner(s): Brutus, Joel F
• Application Number:
  US14/538,698
• Publication Number:
  US 20150148655A1
• Time in Patent Office: 1,813 Days
• Field of Search: None
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 2562/0204 Acoustic sensors
• CPC Class Codes: A61B 5/0064 Body surface scanning
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61B 8/10 Eye inspection
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids

Abstract

A system and method for generating ultrasound images of a subject without physically contacting the subject is provided. A photoacoustic excitation source may be employed that directed into a scanning mirror to transmit acoustic disturbances into a patient to induce propagating photoacoustic waves. The acoustic disturbances are translated along the patient in a defined direction to cause coherent summation of the propagating photoacoustic waves and, thereby, a resultant acoustic and/or elastic wave to probe structures within the patient. Vibrations created by the backscatter of the resultant wave are detected at the surface of the patient and ultrasound images of the structures within the patient are generated. Detection of the vibrations may be performed using a laser vibrometer. The excitation and detection systems may be used separately or in combination.

Claims

1. A method for generating ultrasound images of a patient, the method comprising the steps of:

a) directing a photoacoustic excitation source into a scanning mirror that is configured to transmit acoustic energy into the patient, and translate the acoustic energy in a defined direction at a speed of sound, wherein the acoustic energy induces propagating photoacoustic waves in the patient;

b) translating the acoustic energy along the patient at the speed of sound using the scanning mirror to cause a coherent summation of the propagating photoacoustic waves and, thereby, at least one resultant wave that propagates along the defined direction to probe structures within the patient;

c) detecting vibrations at a surface of the patient created by a backscatter of the least one resultant wave from the structures within the patient; and

d) generating ultrasound images of the structures within the patient using the vibrations detected at the surface of the patient in step c).

2. The method as recited in claim 1, wherein the photoacoustic excitation source includes a laser.

3. The method as recited in claim 2, wherein the laser has one of a continuous wave output and an output with a modulating frequency between about 0 Hz to about 10 MHz.

4. The method as recited in claim 2, wherein the laser produces a laser beam and the scanning mirror is configured to move the laser beam along the defined direction.

5. The method as recited in claim 1, wherein the photoacoustic excitation source includes at least one of a directed source of radio frequency energy and microwave energy.

6. The method as recited in claim 1, wherein detecting vibrations at the surface of the patient created by backscatter of the least one resultant wave is performed using at least one of a laser vibrometer sensing array and an ultrasonic transducer receiver.

7. The method as recited in claim 6, wherein the laser vibrometer sensing array emits a beam of light configured to be delivered to at least one of an eye and skin of the patient.

8. The method as recited in claim 6, wherein the laser vibrometer sensing array is configured to perform Doppler tracking to compensate for movement of the patient.

9. The method as recited in claim 6, wherein the laser vibrometer sensing array is configured to measure the vibrations at the surface of the patient over a frequency band of about 1 Hz to about 40 MHz.

10. The method as recited in claim 6, wherein the laser vibrometer sensing array is at least one of a coherent multipixel imaging system and a digital focal plane array.

11. The method as recited in claim 1, wherein the photoacoustic excitation source includes a handheld device arranged remotely from the patient.

12. The method as recited in claim 1, wherein the ultrasound images include three-dimensional (3D) images and the structures within the patient includes at least one of a brain and a bone.

13. The method as recited in claim 1, wherein at least one of the photoacoustic excitation source and the scanning mirror are configured to translate the acoustic energy at the speed of sound.

14. A system for generating ultrasound images of a patient, the system comprising:

a photoacoustic excitation source configured to direct light into a scanning mirror to produce acoustic energy into the patient inducing propagating photoacoustic waves, wherein the scanning mirror is configured to translate the acoustic energy in a defined direction at a speed of sound;

a sensor configured to detect vibrations at a surface of the patient created by the propagating photoacoustic waves;

a data acquisition system configured to acquire signals corresponding to vibrations detected by the sensor;

a processor having access to the data acquisition system and configured to carry out the steps of;

i) directing at least the scanning mirror to translate the acoustic energy along the patient at the speed of sound to cause a coherent summation of the propagating photoacoustic waves and, thereby, generate at least one resultant wave that propagates along the defined direction to probe structures within the patient;

ii) controlling the data acquisition system to acquire signals corresponding to vibrations at the surface of the patient created by a backscatter of the at least one resultant wave from the structures within the patient; and

iii) generating ultrasound images of the structures within the patient using the signals acquired.

15. The system as recited in claim 14, wherein the photoacoustic excitation source includes a laser.

16. The system as recited in claim 15, wherein the laser has one of a continuous wave output and an output with a modulating frequency between about 0 kHz to about 10 MHz.

17. The system as recited in claim 16, wherein the laser produces a laser beam and the scanning mirror is configured to move the laser beam along the defined direction.

18. The system as recited in claim 14, wherein the photoacoustic excitation source includes at least one of a directed source of radio frequency energy and microwave energy.

19. The system as recited in claim 14, wherein the sensor includes at least one of a laser vibrometer sensing array and an ultrasonic transducer receiver.

20. The system as recited in claim 19, wherein the laser vibrometer sensing array emits a beam of light configured to be delivered to at least one of an eye and skin of the patient.

21. The system as recited in claim 19, wherein the laser vibrometer sensing array is configured to perform Doppler tracking to compensate for movement of the patient.

22. The system as recited in claim 19, wherein the laser vibrometer sensing array is configured to measure the vibrations at the surface of the patient over a frequency band of about 1 Hz to about 40 MHz.

23. The system as recited in claim 19, wherein the laser vibrometer sensing array is at least one of a coherent multipixel imaging system and a digital focal plane array.

24. The system as recited in claim 14, wherein the photoacoustic excitation source includes a handheld device arranged remotely from the patient.

25. The system as recited in claim 14, wherein the ultrasound images include three-dimensional (3D) images and the structures within the patient includes at least one of a brain and a bone.

26. The system as recited in claim 14, wherein at least one of the photoacoustic excitation source and the scanning mirror are configured to translate the acoustic energy at the speed of sound.

27. A method for generating ultrasound images of a patient, the method comprising the steps of:

a) directing a laser beam, produced by a laser source, toward the patient to induce propagating photoacoustic waves therein;

b) translating the laser beam along the patient at a speed of sound using a scanning mirror to cause a coherent summation of the propagating photoacoustic waves and, thereby, at least one resultant wave that propagates along the defined direction to probe structures within the patient, wherein the scanning mirror is configured to translate the laser beam produced by the laser source in a defined direction at the speed of sound;

c) detecting vibrations, using a laser vibrometer sensing array, at a surface of the patient created by a backscatter of the least one resultant wave from the structures within the patient; and

d) generating ultrasound images of the structures within the patient using the vibrations detected at the surface of the patient in step c).

28. The method as recited in claim 27, wherein the laser has one of a continuous wave output and an output with a modulating frequency between about 0 kHz to ab out 10 MHz.

29. The method as recited in claim 27, wherein the laser beam is directed into a scanning mirror configured to move the laser beam along the defined direction.

30. The method as recited in claim 29, wherein at least one of the laser source and the scanning mirror are configured to translate the laser beam at the speed of sound.

31. The method as recited in claim 27, wherein the laser vibrometer sensing array includes an ultrasonic transducer receiver.

32. The method as recited in claim 27, wherein the laser vibrometer sensing array emits a beam of light configured to be delivered to at least one of an eye and skin of the patient.

33. The method as recited in claim 27, wherein the laser vibrometer sensing array is configured to perform Doppler tracking to compensate for movement of the patient.

34. The method as recited in claim 27, wherein the laser vibrometer sensing array is configured to measure the vibrations at the surface of the patient over a frequency band of about 1 Hz to about 40 MHz.

35. The method as recited in claim 27, wherein the laser vibrometer sensing array is at least one of a coherent multipixel imaging system and a digital focal plane array.

36. The method as recited in claim 27, wherein the laser source includes a handheld device arranged remotely from the patient.

37. The method as recited in claim 27, wherein the ultrasound images include three-dimensional (3D) images and the structures within the patient includes at least one of a brain and a bone.

38. The method as recited in claim 27, wherein directing the laser source toward the patient is performed to transmit a acoustic energy into the patient.

39. A system for generating ultrasound images of a patient, the system comprising:

a laser source configured to produce a laser beam configured to induce propagating photoacoustic waves in a patient;

a laser vibrometer sensing array configured to detect vibrations at a surface of the patient created by the propagating photoacoustic waves;

a scanning mirror configured to scan the laser beam produced by the laser source in a defined direction at a speed of sound;

a data acquisition system configured to acquire signals corresponding to vibrations detected by the laser vibrometer sensing array;

a processor having access to the data acquisition system and configured to carry out the steps of;

i) controlling the scanning mirror to translate the laser beam along the patient at the speed of sound to cause a coherent summation of the propagating photoacoustic waves and, thereby, generate at least one resultant wave that propagates along the defined direction to probe structures within the patient;

ii) controlling the data acquisition system to acquire the signals corresponding to vibrations at the surface of the patient created by a backscatter of the at least one resultant wave from the structures within the patient; and

iii) generating ultrasound images of the structures within the patient using the signals acquired.

40. The system as recited in claim 39, wherein the laser has one of a continuous wave output and an output with a modulating frequency between about 0 kHz to about 10 MHz.

41. The system as recited in claim 39, wherein the laser beam is directed into a scanning mirror configured to move the laser beam along the defined direction.

42. The system as recited in claim 41, wherein at least one of the laser source and the scanning mirror are configured to translate the laser beam at the speed of sound.

43. The system as recited in claim 39, wherein the laser vibrometer sensing array includes an ultrasonic transducer receiver.

44. The system as recited in claim 39, wherein the laser vibrometer sensing array emits a beam of light configured to be delivered to at least one of an eye and skin of the patient.

45. The system as recited in claim 39, wherein the laser vibrometer sensing array is configured to perform Doppler tracking to compensate for movement of the patient.

46. The system as recited in claim 39, wherein the laser vibrometer sensing array is configured to measure the vibrations at the surface of the patient over a frequency band of about 1 Hz to about 40 MHz.

47. The system as recited in claim 39, wherein the laser vibrometer sensing array is at least one of a coherent multipixel imaging system and a digital focal plane array.

48. The system as recited in claim 39, wherein the laser source includes a handheld device arranged remotely from the patient.

49. The system as recited in claim 39, wherein the ultrasound images include three-dimensional (3D) images and the structures within the patient includes at least one of a brain and a bone.

50. The system as recited in claim 39, wherein the laser source is directed towards the patient to transmit a acoustic energy into the patient.