Method to determine individualized insulin sensitivity and optimal insulin dose by linear regression, and related systems
First Claim
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1. An insulin delivery system, comprising:
- an insulin delivery mechanism; and
an insulin delivery control system comprising a memory and a processor operatively coupled to the memory, wherein the processor is configured to;
store data associated with a user of the insulin delivery system, the data comprising glucose concentration measurements, insulin dosing information, and dietary carbohydrate information;
determine rates of change of glucose concentrations responsive to the glucose concentration measurements;
train a first learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the insulin dosing information;
train a second learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the dietary carbohydrate information;
receive a time series of dietary carbohydrate intake;
determine glucose responses over a period of time using the first learned time-dependent glucose response model, the second learned time-depend glucose response model, the time-series of dietary carbohydrate intake, and a number of time series of insulin doses;
integrate the glucose responses over the period of time to determine total glucose responses;
determine a time series of insulin doses of the number of time series of insulin doses that minimizes total glucose responses associated with hyperglycemia and hypoglycemia; and
configure the insulin delivery system to provide insulin doses from the insulin delivery mechanism responsive to the determined time series of insulin doses.
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Abstract
This invention relates to a method and a device for predicting the glucose concentration of a subject and recommending therapeutic action. The responses of the user'"'"'s glucose to administered doses of insulin, dietary carbohydrates, and other factors influencing glucose concentration are measured individually for a given user. Once these responses are learned as a function of time, the method and device can receive information about the factors which that have been recently or will soon be administered and can recommend which other factors should also be administered.
10 Citations
21 Claims
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1. An insulin delivery system, comprising:
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an insulin delivery mechanism; and an insulin delivery control system comprising a memory and a processor operatively coupled to the memory, wherein the processor is configured to; store data associated with a user of the insulin delivery system, the data comprising glucose concentration measurements, insulin dosing information, and dietary carbohydrate information; determine rates of change of glucose concentrations responsive to the glucose concentration measurements; train a first learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the insulin dosing information; train a second learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the dietary carbohydrate information; receive a time series of dietary carbohydrate intake; determine glucose responses over a period of time using the first learned time-dependent glucose response model, the second learned time-depend glucose response model, the time-series of dietary carbohydrate intake, and a number of time series of insulin doses; integrate the glucose responses over the period of time to determine total glucose responses; determine a time series of insulin doses of the number of time series of insulin doses that minimizes total glucose responses associated with hyperglycemia and hypoglycemia; and configure the insulin delivery system to provide insulin doses from the insulin delivery mechanism responsive to the determined time series of insulin doses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method, comprising:
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storing data associated with a user of an insulin delivery system, the data comprising glucose concentration measurements, insulin dosing information, and dietary carbohydrate information; determining rates of change of glucose concentration responsive to the glucose concentration measurements; training a first learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the insulin dosing information; training a second learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the dietary carbohydrate information; receiving a time series of dietary carbohydrate intake; determining glucose responses over a period of time using the first learned time-dependent glucose response model, the second learned time-depend glucose response model, the time-series of dietary carbohydrate intake, and a number of time series of insulin doses; integrating the glucose responses over a period of time to determine total glucose responses; determining a time series of insulin doses of the number of time series of insulin doses that minimizes total glucose responses associated with hyperglycemia and hypoglycemia and configuring the insulin delivery system to provide insulin doses from an insulin delivery mechanism responsive to the determined time series of insulin doses. - View Dependent Claims (18, 19, 20, 21)
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Specification