Use of human small leucine zipper protein in osteogenesis procedure
First Claim
Patent Images
1. A screening method to determine if a medicine can prevent or treat bone disease, comprising:
- contacting a cell transformed with human small leucine-zipper proteins (sLZIP) and Peroxisome proliferator-activated receptor γ
2 (PPARγ
2) with a candidate material, wherein either the human sLZIP or PPARγ
2 is coupled to a detectable component; and
detecting an increase in formation of the complex of the human sLZIP and PPARγ
2 in the cell, whereby said candidate material is determined to be a material capable of preventing or treating bone disease.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, sLZIP increases the transcriptional activity of Runx2 and inhibits the transcriptional activity of PPARγ2, thereby increasing the osteoblast differentiation, so that sLZIP performs an important role in the osteogenesis procedure, and thus can be used as a marker for treating bone disease and developing new medicines.
-
Citations
5 Claims
-
1. A screening method to determine if a medicine can prevent or treat bone disease, comprising:
-
contacting a cell transformed with human small leucine-zipper proteins (sLZIP) and Peroxisome proliferator-activated receptor γ
2 (PPARγ
2) with a candidate material, wherein either the human sLZIP or PPARγ
2 is coupled to a detectable component; anddetecting an increase in formation of the complex of the human sLZIP and PPARγ
2 in the cell, whereby said candidate material is determined to be a material capable of preventing or treating bone disease. - View Dependent Claims (2, 3, 4, 5)
-
Specification