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Use of human small leucine zipper protein in osteogenesis procedure

  • US 10,456,446 B2
  • Filed: 04/05/2018
  • Issued: 10/29/2019
  • Est. Priority Date: 04/30/2013
  • Status: Active Grant
First Claim
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1. A screening method to determine if a medicine can prevent or treat bone disease, comprising:

  • contacting a cell transformed with human small leucine-zipper proteins (sLZIP) and Peroxisome proliferator-activated receptor γ

    2 (PPARγ

    2) with a candidate material, wherein either the human sLZIP or PPARγ

    2 is coupled to a detectable component; and

    detecting an increase in formation of the complex of the human sLZIP and PPARγ

    2 in the cell, whereby said candidate material is determined to be a material capable of preventing or treating bone disease.

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