Single pass coronary venous lead for multiple chamber sense and pace

• US 10,456,581 B2
• Filed: 11/18/2016
• Issued: 10/29/2019
• Est. Priority Date: 11/20/2015
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Liu, Lili, Miller, Matthew J., Hoecke, Kyle K., Kunkel, Ronald W.
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US15/356,137
• Publication Number:
  US 20170143968A1
• Time in Patent Office: 1,075 Days
• Field of Search: 607 45, 607123
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a single pass implantable lead configured to be coupled to the implantable medical device and arranged to sense and pace the chambers of a patient'"'"'s heart. The lead may include a proximal region having a plurality of electrodes, a distal region having at least one electrode, and an intermediate region therebetween. The system can sense and pace the right atrium, the left atrium, the right ventricle, and the left ventricle.

Claims

1. A method of pacing a patient'"'"'s heart using an implantable lead including a plurality of proximal electrodes and a plurality of distal electrodes, the implantable lead having a proximal region including at least one of the plurality of proximal electrodes positioned in a coronary sinus or great cardiac vein of the patient'"'"'s heart and a distal region positioned in a coronary vein of the patient'"'"'s heart such that at least one of the plurality of distal electrodes is situated proximate an intraventricular septum of the patient'"'"'s heart, the method comprising:

sensing an atrial and a ventricular signal of the patient'"'"'s heart via at least one of the proximal electrodes and at least one of the distal electrodes, respectively;

determining a pacing threshold associated with each of the plurality of distal electrodes;

selecting at least one of the plurality of distal electrodes that have associated therewith right and left ventricular pacing thresholds; and

delivering a pacing signal to the patient'"'"'s heart via the selected at least one distal electrode, the transmitted pacing signal causing a desired contraction of both the right ventricle and the left ventricle.

2. The method of claim 1, wherein the distal region of the implantable lead is positioned within an anterior coronary vein.

3. The method of claim 1, wherein selecting the at least one of the plurality of distal electrodes includes selecting at least one distal electrode having associated therewith right and left ventricular pacing thresholds below a designated maximum pacing threshold value.

4. The method of claim 1, wherein determining the pacing threshold associated with each of the plurality of distal electrodes further comprises determining a right and left ventricle pacing threshold associated with a first one of the plurality of distal electrodes and determining a right and left ventricle pacing threshold associated with a second one of the plurality of distal electrodes.

5. The method of claim 4, wherein the first one of said plurality of distal electrodes has associated therewith first right and left ventricular pacing thresholds and the second one of the plurality of distal electrodes has associated therewith second right and left ventricular pacing thresholds, the second right and left ventricular pacing thresholds exceeding said first right and left ventricular pacing thresholds.

6. The method of claim 1, further comprising selecting a first one of the plurality of distal electrodes as a right and left ventricular pacing electrode.

7. The method of claim 6, further comprising selecting the first one of the plurality of distal electrodes or a second one of the plurality of distal electrodes as a right and left ventricular sensing electrode.

8. The method of claim 1, further comprising selecting a first one of the plurality of distal electrodes and a second one of the plurality of distal electrodes to operate, in combination, to pace a right ventricle and a left ventricle of the patient'"'"'s heart.

9. The method claim 8, wherein selecting the first one of the plurality of distal electrodes and the second one of the plurality of distal electrodes to operate, in combination, to pace a right ventricle and a left ventricle of the patient'"'"'s heart is based on left and right ventricular pacing thresholds associated with the first and said second ones of the plurality of distal electrodes, in combination, being less than the right and left ventricular pacing thresholds of the first and the second one of the plurality of distal electrodes, individually.

10. The method of claim 1, wherein a first group of the plurality of proximal electrodes is disposed along the implantable lead distal to the at least one proximal electrodes positioned in the coronary sinus or the great cardiac vein of the patient'"'"'s heart, and wherein the method further comprises determining a left atrial pacing threshold associated with a first one of the first group of the plurality of proximal electrodes, and determining a left atrial pacing threshold associated with a second one of said the first group of the plurality of proximal electrodes, wherein the second determined left atrial pacing threshold exceeds the first determined left atrial pacing threshold, and selecting the first one of the first group of the plurality of proximal electrodes as a left atrial pacing electrode based on the second determined left atrial pacing threshold exceeding the first determined left atrial pacing threshold.

11. The method of claim 10, further comprising selecting the first one of the first group of the plurality of proximal electrodes or the second one of the first group of the plurality of proximal electrodes as a left atrial sensing electrode.

12. The method of claim 10, further comprising selecting the first one of the first group of the plurality of proximal electrodes and the second one of the first group of the plurality of proximal electrodes to operate, in combination, to pace the left atrium of the patient'"'"'s heart.

14. The method of claim 12, wherein the first proximal electrode is positioned proximate a coronary sinus ostium within the coronary sinus, and the second proximal electrode is positioned within the coronary sinus or a great cardiac vein and adjacent a myocardium of a left atrium.

13. A method of inserting an implantable lead into a patient'"'"'s heart, the implantable lead having a proximal region including a plurality of proximal electrodes and a distal region including at least one distal electrode, the method comprising:

inserting the implantable lead into the patient'"'"'s heart via a superior vena cava or an inferior vena cava;

positioning the implantable lead such that at least a portion of the proximal region of the single pass implantable lead is positioned within a coronary sinus of the patient'"'"'s heart and at least a portion of the distal region of the single pass implantable lead is positioned within an anterior coronary vein, with the at least one distal electrode being positioned adjacent to an intraventricular septum of the patient'"'"'s heart;

electrically connecting the single pass implantable lead to a pulse generator or an implantable medical device;

selecting a first proximal electrode from the plurality of proximal electrodes to operate as a right atrial pacing electrode based on a measured right atrial pacing threshold associated with the first proximal electrode;

selecting a second proximal electrode from the plurality of proximal electrodes to operate as a left atrial pacing electrode based on a measured left atrial pacing threshold associated with the second proximal electrode; and

selecting a first distal electrode from the at least one distal electrode to operate as a right ventricular and left ventricular pacing electrode based on measured right and left ventricular pacing thresholds associated with the first distal electrode.

15. The method of claim 13, wherein the plurality of proximal electrodes includes at least a third proximal electrode positioned proximate the second proximal electrode and wherein the second proximal electrode is selected based on the measured left atrial pacing threshold associated with the second proximal electrode being less than a measured left atrial pacing threshold associated with the third proximal electrode.

16. The method of claim 15, wherein the third proximal electrode is designated as a left atrial sensing electrode.

17. The method of claim 15, wherein the third proximal electrode is also selected as a left atrial pacing electrode such that the second and the third proximal electrodes operate together to deliver a pacing signal to the patient'"'"'s heart, wherein a measured left atrial pacing threshold of the second and third proximal electrodes, in combination, being less than the measure left atrial pacing threshold of the second and third proximal electrodes individually.

18. The method of claim 13, wherein the plurality of proximal electrodes includes at least a fourth proximal electrode positioned along the single pass lead proximal of the first proximal electrode, the fourth proximal electrode being positioned within a right atrium and being designated as a right atrial sensing electrode.

19. A method of performing biventricular pacing of a patient'"'"'s heart using an implantable lead including one or more proximal electrodes and one or more distal electrodes, the method comprising:

positioning a proximal region of the implantable lead such that the one or more proximal electrodes are positioned in a coronary sinus or the great cardiac vein of the patient'"'"'s heart;

positioning a distal region of the implantable lead in an anterior coronary vein of the patient'"'"'s heart such that the one or more distal electrodes are situated adjacent to an intraventricular septum of the patient'"'"'s heart;

sensing an atrial and a ventricular signal of the patient'"'"'s heart via the one or more proximal electrodes and the one or more distal electrodes;

selecting at least one distal electrode of the one or more distal electrodes having associated therewith right and left ventricular pacing thresholds below a designated pacing threshold;

delivering, via a pulse generator coupled to the implantable lead, a pacing signal to the patient'"'"'s heart via the selected at least one distal electrode, the delivered pacing signal causing a desired contraction of both the right ventricle and the left ventricle.

20. The method of claim 19, wherein the implantable lead includes a plurality of proximal electrodes, a first one of the plurality of proximal electrodes being positioned proximate the coronary sinus ostium of the patient'"'"'s heart, the first one of the proximal electrodes being operable to sense and pace at least the right atrium of the patient'"'"'s heart.