Particle beam scanning

• US 10,456,591 B2
• Filed: 10/27/2017
• Issued: 10/29/2019
• Est. Priority Date: 09/27/2013
• Status: Active Grant

• Current Assignee: Mevion Medical Systems Incorporated
• Original Assignee: Mevion Medical Systems Incorporated
• Inventors: Zwart, Gerrit Townsend, Cooley, James, Franzen, Ken Yoshiki, Jones, Mark R., Li, Tao, Busky, Michael
• Primary Examiner(s): Maskell, Michael
• Application Number:
  US15/796,237
• Publication Number:
  US 20180043181A1
• Time in Patent Office: 732 Days
• Field of Search: 2504921-4923, 250396 R, 250396 ML
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 1/10 Scattering devices; Absorbing devices; Ionising radiation filters
• CPC Class Codes: H01J 2237/30483 Scanning
• CPC Class Codes: H01J 37/14 magnetic
• CPC Class Codes: H05H 13/02 Synchrocyclotrons, i.e. frequency modulated cyclotrons
• CPC Class Codes: H05H 2007/125 by mechanical means, e.g. stripping foils
• CPC Class Codes: H05H 2277/11 Radiotherapy
• CPC Class Codes: H05H 7/12 Arrangements for varying final energy of beam

Abstract

An example particle therapy system includes: a synchrocyclotron to output a particle beam; a magnet to affect a direction of the particle beam to scan the particle beam across at least part of an irradiation target; scattering material that is configurable to change a spot size of the particle beam, where the scattering material is down-beam of the magnet relative to the synchrocyclotron; and a degrader to change an energy of the beam prior to output of the particle beam to the irradiation target, where the degrader is down-beam of the scattering material relative to the synchrocyclotron.

Claims

1. A particle therapy system comprising:

a synchrocyclotron to output a particle beam;

a scanning system to receive the particle beam from the synchrocyclotron and to move the particle beam across at least part of an irradiation target; and

one or more processing devices to control the scanning system to move the particle beam across the at least part of the irradiation target according to an irregular grid pattern, where at least some spots of the particle beam in the irregular grid pattern are not along lines located at regular locations along the at least part of the irradiation target.

2. The particle therapy system of claim 1, wherein, in the irregular grid pattern, spacing between the particle beam varies.

3. The particle therapy system of claim 1, wherein the irregular grid pattern has a perimeter that corresponds to a perimeter of a cross-section of the irradiation target.

4. The particle therapy system of claim 1, wherein a speed of the particle beam between different spots on the at least part of the irradiation target is substantially the same.

5. The particle therapy system of claim 1, further comprising:

memory to store a treatment plan, the treatment plan comprising information to define the irregular grid pattern for the at least part of the irradiation target and also to define irregular grid patterns for other parts of the irradiation target.

6. The particle therapy system of claim 5, wherein different irregular grid patterns for the other parts of the irradiation target have at least one of:

different numbers of spots to be irradiated, different locations of spots to be irradiated, different spacing between spots to be irradiated, or different pattern perimeters.

7. The particle therapy system of claim 1, wherein the scanning system comprises:

a magnet to affect a direction of the particle beam to move the particle beam across the at least part of the irradiation target; and

scattering material that is configurable to change a spot size of the particle beam prior to the particle beam reaching the irradiation target, the scattering material being down-beam of the magnet relative to the synchrocyclotron.

8. The particle therapy system of claim 7, wherein the scanning system further comprises:

an energy degrader to change an energy of the particle beam prior to the particle beam reaching the irradiation target, the energy degrader being down-beam of the scattering material relative to the synchrocyclotron.

9. The particle therapy system of claim 7, wherein the synchrocyclotron comprises:

a voltage source to provide a radio frequency (RF) voltage to a cavity to accelerate particles within the cavity, the cavity having a magnetic field causing the particles accelerated to move orbitally within the cavity;

an extraction channel to receive the particles accelerated and to output the received particles from the cavity as part of the particle beam; and

a regenerator to provide a magnetic field bump within the cavity to thereby change successive orbits of the particles accelerated within the cavity so that, eventually, particles output to the extraction channel;

wherein the magnetic field is between 4 Tesla (T) and 20 T in a center of the cavity.

10. The particle therapy system of claim 9, further comprising:

a gantry on which the synchrocyclotron and at least part of the scanning system are mounted, the gantry being configured to move the synchrocyclotron and the at least part of the scanning system at least part-way around the irradiation target.

24. The particle therapy system of claim 1, wherein the particle therapy system is configured to change a spot size of the particle from location to location on the at least part of the irradiation target;

and

wherein the spot size is changeable on a time scale on the order of tenths of a second.

25. The particle therapy system of claim 1, wherein the particle therapy system is configured to change a spot size of the particle from location to location on the at least part of the irradiation target;

and

wherein the spot size is changeable on a time scale on the order of tens of milliseconds.

28. The particle therapy system of claim 1 wherein the scanning system comprising an energy degrader, the energy degrader being configurable to change an energy of the particle beam prior to the particle beam reaching the at least part of the irradiation target;

and

wherein the particle beam is not interrupted during configuration of at least part of the energy degrader to change the energy of the particle beam prior to the particle beam reaching the at least part of the irradiation target.

30. The particle therapy system of claim 1, wherein at least some spots of the particle beam in the irregular grid pattern are deposited at locations that track a perimeter of the at least part of the irradiation target.

11. A particle therapy system comprising:

a synchrocyclotron to output a particle beam;

a magnet to move the particle beam across at least part of an irradiation target; and

one or more processing devices to control the magnet to move the particle beam across the at least part of the irradiation target according to an irregular grid pattern and to control an energy of the particle beam between scanning of different cross-sections of the irradiation target, where at least some spots of the particle beam in the irregular grid pattern are not along lines located at regular locations along the at least part of the irradiation target.

12. The particle therapy system of claim 11, further comprising:

an energy degrader to change an energy of the particle beam between scanning the different cross-sections of the irradiation target, the energy degrader being down-beam of the magnet relative to the synchrocyclotron;

wherein the one or more processing devices are configured to control movement of one or more parts of the energy degrader to control the energy of the particle beam between scanning the different cross-sections of the irradiation target.

13. The particle therapy system of claim 11, wherein, in the irregular grid pattern, spacing between spots of the particle beam varies.

14. The particle therapy system of claim 11, wherein the irregular grid pattern has a perimeter that corresponds to a perimeter of a cross-section of the irradiation target.

15. The particle therapy system of claim 11, wherein the magnet is controlled to maintain a constant speed of the particle beam between different spots on the at least part of the irradiation target.

16. The particle therapy system of claim 11, further comprising:

memory to store a treatment plan comprising information to define the irregular grid pattern for the at least part of the irradiation target, the treatment plan also defining irregular grid patterns for other parts of the irradiation target.

17. The particle therapy system of claim 16, wherein different irregular grid patterns for the other parts of the irradiation target have at least one of:

different numbers of spots to be irradiated, different locations of spots to be irradiated, different spacing between spots to be irradiated, or different pattern perimeters.

18. The particle therapy system of claim 11, wherein the synchrocyclotron comprises:

a voltage source to provide a radio frequency (RF) voltage to a cavity to accelerate particles within the cavity, the cavity having a magnetic field causing particles accelerated to move orbitally within the cavity;

an extraction channel to receive the particles accelerated and to output the received particles from the cavity as part of the particle beam; and

a regenerator to provide a magnetic field bump within the cavity to thereby change successive orbits of the particles accelerated so that, eventually, particles output to the extraction channel;

wherein the magnetic field is between 4 Tesla (T) and 20 T in a center of the cavity.

19. The particle therapy system of claim 18, further comprising:

a gantry on which the synchrocyclotron and the magnet are mounted, the gantry being configured to move the synchrocyclotron and the magnet at least part-way around the irradiation target.

20. The particle therapy system of claim 11, wherein movement of the particle beam comprises raster scanning.

21. The particle therapy system of claim 11, wherein movement of the particle beam comprises spot scanning.

22. The particle therapy system of claim 11, wherein the synchrocyclotron is a variable-energy machine, and wherein the one or more processing devices are configured to control the energy of the particle beam at least in part by controlling the synchrocyclotron to output the particle beam at a specified energy level.

23. The particle therapy system of claim 11, wherein a speed of the particle beam is different between at least two different pairs of spots on the at least part of the irradiation target.

26. The particle therapy system of claim 11, wherein the particle therapy system is configured to change a spot size of the particle from location to location on the at least part of the irradiation target;

and

wherein the spot size is changeable on a time scale on the order of tenths of a second.

27. The particle therapy system of claim 11, wherein the particle therapy system is configured to change a spot size of the particle from location to location on the at least part of the irradiation target;

and

wherein the spot size is changeable on a time scale on the order of tens of milliseconds.

29. The particle therapy system of claim 11, further comprising:

an energy degrader comprising plates that are configurable to change an energy of the particle beam prior to the particle beam reaching the at least part of the irradiation target;

wherein the one or more processing devices are configured to control the energy of the particle beam by controlling movement of the plates into and out of a treatment field; and

wherein output of the particle beam by the synchrocyclotron is not interrupted during configuring the plates to change the energy of the particle beam prior to the particle beam reaching the at least part of the irradiation target.

31. The particle therapy system of claim 11, wherein at least some spots of the particle beam in the irregular grid pattern are deposited at locations that track a perimeter of the at least part of the irradiation target.