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Optogenetic probes for measuring membrane potential

  • US 10,457,715 B2
  • Filed: 11/28/2016
  • Issued: 10/29/2019
  • Est. Priority Date: 06/18/2014
  • Status: Active Grant
First Claim
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1. A polynucleotide encoding a polypeptide having at least 80% identity to SEQ ID NO:

  • 1, wherein the polypeptide comprises, relative to SEQ ID NO;

    1, at leasta first substitution mutation selected from the group consisting of D95Q and D106H; and

    a second substitution mutation selected from the group consisting of P60S, T80S, and F161V.

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