IGF-1R antibody and its use for the diagnosis of cancer
First Claim
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1. An IGF-1R antibody, or an antigen-binding fragment thereof, said antibody comprising:
- i) a heavy chain comprising the following three CDRs, respectively CDR-H1 of sequence SEQ ID No. 1, CDR-H2 of sequence SEQ ID No. 2 and CDR-H3 of sequence SEQ ID No. 3; and
ii) a light chain comprising the following three CDRs, respectively CDR-L1 of sequence SEQ ID No. 4, CDR-L2 of sequence SEQ ID No. 5 and CDR-L3 of sequence SEQ ID No. 6.
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Abstract
The present disclosure relates to a novel antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody.
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Citations
24 Claims
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1. An IGF-1R antibody, or an antigen-binding fragment thereof, said antibody comprising:
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i) a heavy chain comprising the following three CDRs, respectively CDR-H1 of sequence SEQ ID No. 1, CDR-H2 of sequence SEQ ID No. 2 and CDR-H3 of sequence SEQ ID No. 3; and ii) a light chain comprising the following three CDRs, respectively CDR-L1 of sequence SEQ ID No. 4, CDR-L2 of sequence SEQ ID No. 5 and CDR-L3 of sequence SEQ ID No. 6. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 23, 24)
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3. An IGF-1R antibody secreted by the hybridoma deposited at the CNCM, Institut Pasteur, Paris, on Sep. 17, 2014, under number 1-4893.
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19. A murine hybridoma capable of secreting an IGF-1R antibody or an antigen-binding fragment thereof, said murine hybridoma being deposited at the CNCM, Institut Pasteur, Paris, on Sep. 17, 2014, under number I-4893.
Specification